Development of Novel Tavapadon Analogs as Dual-targeted Partial Agonists Based on the Dopamine D<sub>1</sub>/D<sub>5</sub> Receptors

Development of Novel Tavapadon Analogs as Dual-targeted Partial Agonists Based on the Dopamine D<sub>1</sub>/D<sub>5</sub> Receptors

Tavapadon is a potent, selective G protein-biased partial agonist for the dopamine D1/D5 receptors, with positive experimental results in phase 3 trials for the treatment of Parkinson's disease (PD). This study aims to study the structure–activity relationship (SAR) of tavapadon to discover nov...

Full description

Saved in:
Bibliographic Details
Main Authors: Fan Shi, Jian Jia, Zhijing Hu, Yini Yang, Peng Xie, Zehong Wan, Guan Wang
Format: Article
Language:English
Published: Georg Thieme Verlag KG
Series:Pharmaceutical Fronts
Subjects:
dopamine 1 receptor
dopamine 5 receptor
partial agonists
tavapadon
EC50
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/a-2638-1667
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items