Pterostilbene mitigates experimental pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition

QR Code

Pterostilbene mitigates experimental pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition

BackgroundThe natural compound pterostilbene (PTE) has multiple cardiovascular protective effects. However, its effects on pulmonary arterial hypertension (PAH)-associated vascular remodeling remain to be elucidated. This study investigated the effects of PTE on monocrotaline (MCT)-induced PAH in ra...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jie Wang, Yu Zhang, Junjun Liu, Fan Jiang, Xiaopei Cui, Weida Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Pharmacology
Subjects:	pterostilbene pulmonary arterial hypertension endothelial-to-mesenchymal transition high mobility group AT-hook SNAI twist
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1621700/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Anti-aging Efficacy of a 0.1 % Pterostilbene Skincare Emulsion: A 28-Day Clinical Trial
by: Zongxiao Cen, et al.
Published: (2025-06-01)

Stability and efficacy of pterostilbene nanoliposomes in cosmetic applications: A comprehensive study
by: Jianxin Li, et al.
Published: (2024-12-01)

INDUCTION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION IN MCF-7-SNAI1 CELLS LEADS TO REORGANIZATION OF ADHERENS JUNCTIONS AND ACQUISITION OF MIGRATORY ACTIVITY
by: I. Y. Zhitnyak, et al.
Published: (2018-09-01)

Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO‐1 pathways
by: Chang Xu, et al.
Published: (2021-12-01)

Comparing the effectiveness of pterostilbene and sitagliptin on modulating inflammatory levels and inducing autophagy to improve atherosclerosis outcome: A preclinical study in rabbits [version 4; peer review: 2 approved]
by: Wisam J Mohammed, et al.
Published: (2025-05-01)

Tumour Budding with Epithelial Mesenchymal Transition Markers – A Novel Prognostic Tool for Breast Carcinoma
by: Priyadharshini Kumar, et al.
Published: (2025-04-01)

High Sensitive Directional Twist Sensor Based on a Mach–Zehnder Interferometer
by: Shujie Duan, et al.
Published: (2018-01-01)

An Optical Fiber Twist Sensor With Temperature Compensation Mechanism Based on T-SMS Structure
by: Yujian Li, et al.
Published: (2020-01-01)

Vše, co jste chtěli vědět o feminismu…
by: Kateřina Machovcová
Published: (2014-08-01)

Twin Photonic Hooks Generated by Twin-Ellipse Microcylinder
by: Xingliang Shen, et al.
Published: (2020-01-01)

Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling
by: Lv P, et al.
Published: (2025-07-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

Super‐Heterostructures of Twisted Pd Nanoarrays Epitaxially Grown on Chiral Au Nanorods Boost Circularly Polarized Photocatalysis
by: Taotao Luo, et al.
Published: (2025-07-01)

Engineered Mesenchymal Stem Cell–Derived Extracellular Vesicles Reverse Endothelial–Mesenchymal Transition in Atherosclerosis
by: Zhuo Chen, et al.
Published: (2025-06-01)

WDR2 regulates the orphan kinesin KIN-G to promote hook complex and Golgi biogenesis in Trypanosoma brucei
by: Qing Zhou, et al.
Published: (2025-07-01)

Characterization and Differentiation into Adipocytes and Myocytes of Porcine Bone Marrow Mesenchymal Stem Cells
by: Min-qing DU, et al.
Published: (2014-04-01)

Synergies of accelerating differentiation of bone marrow mesenchymal stem cells induced by low intensity pulsed ultrasound, osteogenic and endothelial inductive agent
by: Ruixin He, et al.
Published: (2019-12-01)

Infantile hepatic hemangioma and hepatic mesenchymal hamartoma in an infant associated with placental mesenchymal dysplasia: a case report
by: Shunsuke Fujii, et al.
Published: (2022-08-01)

Modulation of phosphatase of regenerating liver-1 within placental mesenchymal stem cells instigates the transition between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition subsequent to hepatic fibrosis
by: Jae Yeon Kim, et al.
Published: (2025-07-01)

USING MESENCHYMAL STEM CELLS FOR TREATING GINGIVAL RECESSION IN THE EXPERIMENT
by: S. P. Rubnikovich, et al.
Published: (2018-10-01)

TREX1 activators: A novel therapeutic strategy for rheumatoid arthritis management via cfDNA clearance
by: Yuping Wang, et al.
Published: (2025-08-01)

Versuch einer Stilanalyse der Aufhangehaken vom Mittleren Sepik in Neu-Guinea /
by: Schefold, Reimar
Published: (1966)

The hook test for rupture of tibialis anterior tendon
by: Om Lahoti
Published: (2025-01-01)

Crossbow Part Finds from the Territory of Mazovia and Dobrzyń Land
by: Jarosław Ościłowski
Published: (2021-12-01)

Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe feline chronic kidney disease
by: Yizhe Song, et al.
Published: (2025-07-01)

Olfactory mucosal mesenchymal stem cells delivered by gelatin sponge scaffolds promote functional recovery of spinal cord injury
by: Wenshui Li, et al.
Published: (2025-07-01)

Exploration of Cytokines That Impact the Therapeutic Efficacy of Mesenchymal Stem Cells in Alzheimer’s Disease
by: Herui Wang, et al.
Published: (2025-06-01)

PMSM Sensorless Direct Torque Control System with Improved STSMO
by: LÜ Degang, et al.
Published: (2024-04-01)

Mesenchymal Cystic Hamartoma of the Lung
by: A. N. Fedotov, et al.
Published: (2024-01-01)

DETERMINATION OF COMMERCIAL AIRCRAFT WING GEOMETRY DURING THE FLIGHT
by: V. I. Shevyakov
Published: (2016-11-01)

Isolated Rupture of Extraocular Muscles in a Severe Penetrating Trauma – “A Globe Shielded by Muscles”
by: Shashikant Shetty, et al.
Published: (2025-04-01)

Treatment of epilepsy with mesenchymal stem cells: literature review
by: R. G. Gamirova, et al.
Published: (2023-06-01)

EXPRESSION OF PROTEIN GENES PARTICIPATING IN FIBROPLASTIC PROCESSES IN MICE LUNG DURING THE DEVELOPMENT OF TUBERCULOUS INFLAMMATION
by: P. M. Kozhin, et al.
Published: (2019-09-01)

Treatment effects of human amnion-derived mesenchymal stem cells for skin lesions and metastatic pulmonary calcification in calciphylaxis patients – case series and literature review
by: Shijiu Lu, et al.
Published: (2025-12-01)

Propofol inhibits proliferation and metastasis by up-regulation of miR-495 in JEG-3 choriocarcinoma cells
by: Hai Sun, et al.
Published: (2019-12-01)

The Particularities of Morphology of the <i>Callopsylla caspia</i> Representatives from Different Parts of Its Areal
by: A. I. Goncharov, et al.
Published: (2010-06-01)

Chronology and Evolution of Early Medieval Hooked Spurs in the Light of New Finds and Analyses
by: Andrzej Janowski
Published: (2016-11-01)

The interplay of autophagy and epithelial-to-mesenchymal transition in cancer progression
by: O. O. Ryabaya, et al.
Published: (2020-09-01)