The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative Review
This narrative review explores the potential therapeutic role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) in the management of Polycystic Ovary Syndrome (PCOS). PCOS is a multifaceted challenge affecting women, often associated with genetic susceptibility, obesity, and insulin resistan...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-07-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/61264 |
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| author | Kamil Turlej Dmytro Kowalczuk Viktoryia Kasianik Darya Lazitskaya Mykola Sobchynskyi Valeryia Milasheuskaya Andrii Myrnyi Iga Kiełbaszewska Natallia Surosz Katsiaryna Miraniuk |
| author_facet | Kamil Turlej Dmytro Kowalczuk Viktoryia Kasianik Darya Lazitskaya Mykola Sobchynskyi Valeryia Milasheuskaya Andrii Myrnyi Iga Kiełbaszewska Natallia Surosz Katsiaryna Miraniuk |
| author_sort | Kamil Turlej |
| collection | DOAJ |
| description |
This narrative review explores the potential therapeutic role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) in the management of Polycystic Ovary Syndrome (PCOS). PCOS is a multifaceted challenge affecting women, often associated with genetic susceptibility, obesity, and insulin resistance. The review seeks to provide a nuanced understanding of the interconnected health concerns of obesity and infertility in women with PCOS and critically analyse current data on the use of GLP-1 RAs as a potential treatment strategy in comparison to standard management of PCOS. It focuses on evaluating their impact on weight loss and associated metabolic parameters, drawing upon evidence from preclinical and clinical studies. While promising results have been observed, including potential benefits on endocrine and reproductive parameters, concerns regarding long-term safety, including serious adverse events, warrant further investigation. This review aims to summarise the current understanding of GLP-1 RAs in PCOS and highlight areas requiring additional research to fully establish their place in comprehensive PCOS management.
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| format | Article |
| id | doaj-art-2e37f2c50f4c4e2597c7a55fb9463f68 |
| institution | Matheson Library |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-2e37f2c50f4c4e2597c7a55fb9463f682025-07-11T07:28:44ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-07-014310.12775/QS.2025.43.61264The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative ReviewKamil Turlejhttps://orcid.org/0009-0008-2919-284XDmytro Kowalczukhttps://orcid.org/0009-0004-1433-5052Viktoryia Kasianikhttps://orcid.org/0009-0004-1540-5227Darya Lazitskayahttps://orcid.org/0009-0007-8680-8826Mykola Sobchynskyihttps://orcid.org/0009-0008-1804-1114Valeryia Milasheuskayahttps://orcid.org/0009-0006-4126-2375Andrii Myrnyihttps://orcid.org/0009-0006-5592-259XIga Kiełbaszewska0https://orcid.org/0009-0004-9892-4769Natallia Suroszhttps://orcid.org/0009-0005-1939-151XKatsiaryna Miraniukhttps://orcid.org/0009-0006-1406-9756Doc. Adama Dowgirda 9, 17-200 Hajnówka, Poland This narrative review explores the potential therapeutic role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) in the management of Polycystic Ovary Syndrome (PCOS). PCOS is a multifaceted challenge affecting women, often associated with genetic susceptibility, obesity, and insulin resistance. The review seeks to provide a nuanced understanding of the interconnected health concerns of obesity and infertility in women with PCOS and critically analyse current data on the use of GLP-1 RAs as a potential treatment strategy in comparison to standard management of PCOS. It focuses on evaluating their impact on weight loss and associated metabolic parameters, drawing upon evidence from preclinical and clinical studies. While promising results have been observed, including potential benefits on endocrine and reproductive parameters, concerns regarding long-term safety, including serious adverse events, warrant further investigation. This review aims to summarise the current understanding of GLP-1 RAs in PCOS and highlight areas requiring additional research to fully establish their place in comprehensive PCOS management. https://apcz.umk.pl/QS/article/view/61264PCOSGLP-1 receptor agonistsinferitilitymaternal obesity |
| spellingShingle | Kamil Turlej Dmytro Kowalczuk Viktoryia Kasianik Darya Lazitskaya Mykola Sobchynskyi Valeryia Milasheuskaya Andrii Myrnyi Iga Kiełbaszewska Natallia Surosz Katsiaryna Miraniuk The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative Review Quality in Sport PCOS GLP-1 receptor agonists inferitility maternal obesity |
| title | The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative Review |
| title_full | The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative Review |
| title_fullStr | The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative Review |
| title_full_unstemmed | The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative Review |
| title_short | The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists in Polycystic Ovary Syndrome: A Narrative Review |
| title_sort | potential role of glucagon like peptide 1 receptor agonists in polycystic ovary syndrome a narrative review |
| topic | PCOS GLP-1 receptor agonists inferitility maternal obesity |
| url | https://apcz.umk.pl/QS/article/view/61264 |
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