Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

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Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal damage and impaired epithelial barrier function. While glycyl-l-histidyl-l-lysine-copper (GHK-Cu) exhibits known anti-inflammatory properties, its therapeutic mechanisms in UC remain undefined....

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Bibliographic Details
Main Authors:	Shuzhen Mao, Jiahui Huang, Junyan Li, Fang Sun, Qilian Zhang, Qing Cheng, Wei Zeng, Dongya Lei, Shiyan Wang, Jing Yao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Pharmacology
Subjects:	ulcerative colitis GHK-Cu SIRT1/STAT3 pathway co-culture system network pharmacology molecular docking
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1551843/full
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