Cerium oxide nanoparticles in vivo distribution and transformation behavior mediate intestinal transit function
CeO2 nanoparticles (NPs) could be exposed to all levels of food chain organisms during generation or utilization, and the possible effects on intestinal microecosystem by potential human ingestion deserves to be scrutinized. However, the effects of continuous ingestion with CeO2 NPs on distribution...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artykuł |
| Język: | angielski |
| Wydane: |
Elsevier
2025-09-01
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| Seria: | Ecotoxicology and Environmental Safety |
| Hasła przedmiotowe: | |
| Dostęp online: | http://www.sciencedirect.com/science/article/pii/S0147651325009820 |
| Etykiety: |
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| Streszczenie: | CeO2 nanoparticles (NPs) could be exposed to all levels of food chain organisms during generation or utilization, and the possible effects on intestinal microecosystem by potential human ingestion deserves to be scrutinized. However, the effects of continuous ingestion with CeO2 NPs on distribution and intestinal physiological function are not known. This work showed the distribution in vivo, and the potential biochemical mechanisms in Ce3 + /Ce4+ electron conversion mediated the elimination of reactive oxygen species (ROS) with the co-involvement of intestinal microbes after CeO2 NPs (10 mg/kg·bw/day, 28 days) continuous ingestion in mice. CeO2 NPs can be mostly excreted in feces (51.49 %), yet the rest existed at different levels in all tissues, and with the highest levels in digestive tissues (stomach (36.78 %) and intestine (4.44 %)). CeO2 NPs exhibited higher accumulation in intestine with low transporter capacity and further participate in redox processes, ultimately alleviating transport function disruption. Importantly, electron transfer from Ce3+ to Ce4+ took a major role in H2O2 to H2O production, where the H2O2 level was reduced by 32.92 %. Further, CeO2 NPs electron transfer reduced intestinal microbial extracellular oxidase combinatorial role in ROS. These results suggested that after CeO2 NPs ingestion, electron transfer between Ce3+ and Ce4+ modulates the intestinal redox microcosm and mitigates the reduction of persistent transport capacity. Therefore, this work provides more accurate descriptions of the entire physiological process of CeO2 NPs after ingestion, spotlights their intestinal transport fate and redox functional effects, and opens up new theoretical perspectives for potential human health studies of NPs. |
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| ISSN: | 0147-6513 |