The role of colchicine therapy in the treatment of postpericardiotomy syndrome
Introduction: Postpericardiotomy syndrome is a common condition among pericardial diseases in clinical practice. The aim of our study was to survey the incidence and treatment options of postpericardiotomy syndrome during the early rehabilitation following open-heart surgery. Patients and methods:...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Promenade Kft
2025-07-01
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| Series: | Cardiologia Hungarica |
| Subjects: | |
| Online Access: | https://cardiologia.hungarica.eu/archive/2025-issues/2025-3-contents/the-role-of-colchicine-therapy-in-the-treatment-of-postpericardiotomy-syndrome |
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| Summary: | Introduction: Postpericardiotomy syndrome is a common condition among pericardial diseases in clinical practice. The aim of our study was to survey the incidence and treatment options of postpericardiotomy syndrome during the early rehabilitation following open-heart surgery.
Patients and methods: Our retrospective consecutive study is based on data from patients referred from one cardiac surgery center over a six-month period. 174 patients who had undergone open-heart surgery (mean age 64.49±10.86 years, 125 males) were included in our work, with an average rehabilitation stay of 20.07±4.32 days. The amount of pericardial fluid was measured using echocardiography. The postpericardiotomy syndrome was diagnosed according to the European Society of Cardiology’s definition and the CRP threshold of 50 mg/L observed during the study. Our data analysis included descriptive statistics, two-sample t-tests, chi-square tests, and simple logistic regression
Results: Postpericardiotomy syndrome developed in 48.1% of our patients, with 23.7% receiving colchicine therapy. During rehabilitation, one of the most frequently checked and most important parameters of the syndrome was the change in pericardial fluid volume. In patients with postpericardiotomy syndrome who had pericardial fluid accumulation below 20 mm and received colchicine therapy, the initial fluid volume (7.31±4.70 mm) significantly decreased (3.06±3.96 mm; P=0.0005). Analysis of potential predisposing factors suggested that hyperuricemia (p=0.033) might be associated with the development of the syndrome.
Conclusions: Colchicine therapy administered during rehabilitation after open-heart surgery significantly reduced pericardial fluid volume in patients with postpericardiotomy syndrome. We hypothesize that the treatment may play a particularly important role in patients with hyperuricemia; however, further studies are needed to confirm this. |
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| ISSN: | 0133-5596 1588-0230 |