SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma

QR Code

SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma

Background: Drug resistance prominently hampers the effects of sorafenib in hepatocellular carcinoma (HCC). Epigenetics play important roles in drug resistance. However, the contributions of SET And MYND Domain Containing 2 (SMYD2) to sorafenib resistance in HCC remain unknown. This study is aimed a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Series:	Neoplasia: An International Journal for Oncology Research
Subjects:	SMYD2 Cancer stem cells BMP4 Hepatocellular carcinoma Sorafenib resistance
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558625000831
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway
by: Qing-Feng Xiang, et al.
Published: (2019-12-01)

Successful two-stage operation for esophageal necrosis due to proton beam therapy followed by sorafenib in a case of large hepatocellular carcinoma
by: Eiji Higaki, et al.
Published: (2020-06-01)

Identification of SMYD2 as a candidate diagnostic and prognostic biomarker for gastric cancer
by: Sichao Wang, et al.
Published: (2025-07-01)

ATF7IP inhibits Sorafenib-induced ferroptosis in hepatocellular carcinoma cells by inhibiting CYB5R2 transcription and stabilizing PARK7 protein
by: Yijie Su, et al.
Published: (2025-09-01)

Decoding Drug Interactions: Character and Degree of Pharmacokinetic Interactions Between Telmisartan and Sorafenib or Donafenib in Rats
by: Li Y, et al.
Published: (2025-07-01)

In vivo assessment of pharmacokinetic interactions of empagliflozin and henagliflozin with sorafenib: an animal-based study
by: Wenyu Du, et al.
Published: (2025-07-01)

Antitumor activity of sorafenib on colorectal cancer
by: Turgut Kacan, et al.
Published: (2016-08-01)

An Fe(III)-covalent organic framework (COF)–sorafenib nanoplatform induces chemo-ferroptosis for enhanced hepatocellular carcinoma immunotherapy
by: Binglong Bai, et al.
Published: (2025-10-01)

Holoprosencephaly and cyclopia in bmp7b and bmpr1ba Crispant zebrafish
by: Valentyn Kyrychenko, et al.
Published: (2025-12-01)

Tyrosine kinase inhibitors were well-tolerated among patients with different etiologies of advanced HCC with lower survival in non-viral patients
by: Eman M. F. Barakat, et al.
Published: (2025-06-01)

PHARMACOECONOMICAL RESEARCH OF THE USE OF SORAFENIB IN MALIGNANT TUMORS
by: M. Y. Frolov, et al.
Published: (2016-09-01)

Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma
by: Yao Yao, et al.
Published: (2019-12-01)

Investigating SMYD3 role during oocyte maturation in a 3D follicle-enclosed oocyte in vitro model in sheep
by: Chiara Camerano Spelta Rapini, et al.
Published: (2025-06-01)

Approaches to conducting a physiologically relevant test (PRT) in the study of medicines containing substance IIc of the BCS subclass using sorafenib as an example
by: A. V. Suvorova, et al.
Published: (2024-09-01)

Development of Green RP-HPLC method for determination of sorafenib in film-coated tablets
by: Sanija Zulfikjari, et al.
Published: (2024-12-01)

Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan
by: Sh. Kh. Gantsev, et al.
Published: (2020-11-01)

Co-Assembled Nanoparticles Comprising Sorafenib and Hederagenin Derivative for Enhanced Anti-Hepatic Fibrosis Activity
by: Lu M, et al.
Published: (2025-07-01)

Sorafenib induces ferroptosis in human renal cell carcinoma cells through CCAT/enhancer-binding protein homologous protein
by: Dinh Thi Nhung, et al.
Published: (2025-09-01)

THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT
by: V. A. Gorbunova, et al.
Published: (2017-04-01)

Emerging trends and knowledge networks in pan-cancer sorafenib resistance: a 20-year bibliometric investigation
by: Qiong Zhou, et al.
Published: (2025-07-01)

Biomimetic periosteum combining BMP-2-loaded M2 macrophage-derived exosomes for enhanced bone defect repair
by: Feng Ling, et al.
Published: (2025-08-01)

Association of plasma BMP6 levels with the rates of brain atrophy in older people without dementia
by: Xin Zhang, et al.
Published: (2025-07-01)

LOW DOSE CYTARABINE PLUS SORAFENIB IN AN ELDERLY PATIENT WITH ACUTE MYELOID LEUKEMIA
by: Tural Mahmudov
Published: (2025-07-01)

BMP-2-releasing gelatin microspheres/PLGA scaffolds for bone repairment of X-ray-radiated rabbit radius defects
by: Peng Xia, et al.
Published: (2019-12-01)

PENGARUH PEMBERIAN EKSTRAK DAUN SIRSAK TERHADAP DERAJAT HISTOPATOLOGI PADA TIKUS WISTAR KARSINOMA HEPATOSELULER YANG MENDAPAT TERAPI STANDAR SORAFENIB
by: Nanda Putri Mardiana Sinaga, et al.
Published: (2019-10-01)

Harnessing multi-omics and artificial intelligence: revolutionizing prognosis and treatment in hepatocellular carcinoma
by: Zhen Wang, et al.
Published: (2025-07-01)

The protective role of BMP-15 in infertility development with NLRP3 and IL-18 in infertility development in obese patients with PCOS: clinical and mouse model investigations
by: Qiaohong Guo, et al.
Published: (2025-12-01)

miR-129-1-3p inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells via BMP2/SMAD1 signaling pathway
by: GENG Mingzhu, MU Wenqing, QIU Lin, ZHANG Wei
Published: (2025-06-01)

PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation
by: Li He, et al.
Published: (2025-07-01)

FAK mediates BMP9-induced osteogenic differentiation via Wnt and MAPK signaling pathway in synovial mesenchymal stem cells
by: Weiwei Zheng, et al.
Published: (2019-12-01)

CLINICAL EXPERIENCE OF NEXAVAR (SORAFENIB) APPLICATION IN PATIENTS WITH METASTATIC DIFFERENTIATED THYROID CANCER RESISTANT TO THERAPY 131I
by: P. A. Isaev, et al.
Published: (2015-04-01)

Combination of Hepatic Arterial Infusion Chemotherapy with Tyrosine Kinase Inhibitor Provides Better Survival in Advanced Hepatocellular Carcinoma Patients
by: Liu CW, et al.
Published: (2025-05-01)

Evaluating the Accuracy of BMP280 and BME280 Sensors for Sea Level in a Coastal Environment: A Field Study at Tanjung Siambang Pier
by: Hollanda Arief Kusuma, et al.
Published: (2023-06-01)

3D printed scaffolds loaded with BMP-2 for bone defect regeneration: a systematic review and meta-analysis
by: Lei Li, et al.
Published: (2025-07-01)

SNP variation landscape of BMP15 gene from 75 global sheep breeds and their genetic effect on lambing traits
by: Peiyao Liu, et al.
Published: (2025-07-01)

Antimycobacterial and immunomodulatory activities of sorafenib in a preclinical mouse model of TB infection through CD4+CD25low and CD8+CD25low effector T cells
by: Raju S. Rajmani, et al.
Published: (2025-07-01)

Clinicopathological features and treatment outcomes of patients with fibrolamellar hepatocellular carcinoma: a retrospective multicenter study
by: Ali Kaan Güren, et al.
Published: (2025-07-01)

The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma
by: Zhaoqi Shi, et al.
Published: (2025-09-01)

Genetic variants of BMP15 and BMPR-IB genes and association with litter size in pig
by: SONG Yi-ping, et al.
Published: (2010-09-01)

Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism
by: Han F, et al.
Published: (2025-05-01)