Jinkui Shenqi Pill accelerates osteoporotic fracture healing by promoting bone formation through neurosensory PGE2/EP4/p-CREB axis

Jinkui Shenqi Pill accelerates osteoporotic fracture healing by promoting bone formation through neurosensory PGE2/EP4/p-CREB axis

PurposeJinkui Shenqi Pill (JKSQP), a traditional Chinese herbal formula, is clinically utilized in China for managing bone disorders secondary to kidney deficiency, including osteoporotic fractures (OPFs). The present study aims to elucidate the pharmacological mechanism underlying JKSQP’s therapeut...

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Bibliographic Details
Main Authors: Jihao Xi, Danqing Fu, Dan Xu, Ruhan Shen, Yan Zhao, Haoqiang Dai, Chenjie Xia, Peihong Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
Jinkui Shenqi Pills
osteoporotic fracture
bone formation
sensory nerve
PGE2/EP4/p-CREB axis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1570685/full
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