Nematocidal Activity of a Variety of Plants Used in Mexico Against <i>Strongyloides venezuelensis</i>
Strongyloidiasis represents a public health problem in tropical and subtropical regions. The medicinal plants demonstrate the potential of plants as a source of molecules with helminthic activity. In this research, we assessed the potential of five extracts medicinally used in Mexico against <i&g...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Parasitologia |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-6772/5/2/18 |
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| Summary: | Strongyloidiasis represents a public health problem in tropical and subtropical regions. The medicinal plants demonstrate the potential of plants as a source of molecules with helminthic activity. In this research, we assessed the potential of five extracts medicinally used in Mexico against <i>Strongyloides venezuelensis</i> third-stage infective larvae (L3). Plant methanol (MeOH) extracts of <i>Argemone mexicana</i> (chicalote), <i>Jatropha dioica</i> (Sangre de Drago), <i>Lippia graveolens</i> (oregano), <i>Thymus vulgaris</i> (tomillo), and <i>Kalanchoe daigremontiana</i> (aranto) were prepared by the maceration technique. The toxicity of the extracts was evaluated in human red blood cells by the hemolysis test and in monkey kidney epithelial cells (Vero cells) using the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In addition, we showed their antioxidant potential by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The methanolic extracts of <i>A. mexicana</i>, <i>J. dioica</i>, <i>L. graveolens</i>, and <i>T. vulgaris</i> exhibited significant activity against L3 cultures at 72 and 96 h post-incubation. None of the extracts showed hemolytic effects on red cells or Vero cells. <i>L. graveolens</i> demonstrated the strongest antioxidant activity, with an EC<sub>50</sub> of 19.80 µg/mL. Plant MeOH extracts used in this study showed a promising anthelmintic effect in vitro, making it a suitable candidate for future research in nematocidal therapies. |
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| ISSN: | 2673-6772 |