The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis
Mastitis, an inflammatory condition of the breast, significantly affects breastfeeding women and can lead to the early cessation of lactation. This article explores the pathophysiology of mastitis, distinguishing between acute mastitis (AM) and subacute mastitis (SAM), with a focus on the microbial...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/13/6/176 |
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| author | Mariarosaria Matera Chiara Maria Palazzi Alexander Bertuccioli Francesco Di Pierro Nicola Zerbinati Massimiliano Cazzaniga Aurora Gregoretti Ilaria Cavecchia |
| author_facet | Mariarosaria Matera Chiara Maria Palazzi Alexander Bertuccioli Francesco Di Pierro Nicola Zerbinati Massimiliano Cazzaniga Aurora Gregoretti Ilaria Cavecchia |
| author_sort | Mariarosaria Matera |
| collection | DOAJ |
| description | Mastitis, an inflammatory condition of the breast, significantly affects breastfeeding women and can lead to the early cessation of lactation. This article explores the pathophysiology of mastitis, distinguishing between acute mastitis (AM) and subacute mastitis (SAM), with a focus on the microbial dynamics involved. AM is primarily associated with <i>Staphylococcus aureus</i>, while SAM is linked to a dysbiotic milk microbiota characterized by an imbalance of microbial species, including increased levels of opportunistic pathogens. The role of inflammation and the gut–breast axis in the development of mastitis are discussed, emphasizing the importance of maintaining a healthy microbiota. Recent studies highlight the potential of probiotics as a preventive and therapeutic measure against mastitis, showing promising results in reducing incidence and recurrence. However, further research is necessary to optimize probiotic strains, dosages, and treatment protocols. This review underscores the need for a comprehensive understanding of the microbiological, immunological, and inflammatory factors involved in mastitis to develop effective prevention and treatment strategies. |
| format | Article |
| id | doaj-art-2b660e2d105e4e1c9899e16c6e5ea37b |
| institution | Matheson Library |
| issn | 2079-9721 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj-art-2b660e2d105e4e1c9899e16c6e5ea37b2025-06-25T13:42:58ZengMDPI AGDiseases2079-97212025-06-0113617610.3390/diseases13060176The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal MastitisMariarosaria Matera0Chiara Maria Palazzi1Alexander Bertuccioli2Francesco Di Pierro3Nicola Zerbinati4Massimiliano Cazzaniga5Aurora Gregoretti6Ilaria Cavecchia7Department of Pediatric Emergencies, Misericordia Hospital, 58100 Grosseto, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyMedicine and Technological Innovation Department, University of Insubria, 21100 Varese, ItalyScientific & Research Department, Velleja Research, 20125 Milano, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyMicrobiota International Clinical Society, 10123 Torino, ItalyMastitis, an inflammatory condition of the breast, significantly affects breastfeeding women and can lead to the early cessation of lactation. This article explores the pathophysiology of mastitis, distinguishing between acute mastitis (AM) and subacute mastitis (SAM), with a focus on the microbial dynamics involved. AM is primarily associated with <i>Staphylococcus aureus</i>, while SAM is linked to a dysbiotic milk microbiota characterized by an imbalance of microbial species, including increased levels of opportunistic pathogens. The role of inflammation and the gut–breast axis in the development of mastitis are discussed, emphasizing the importance of maintaining a healthy microbiota. Recent studies highlight the potential of probiotics as a preventive and therapeutic measure against mastitis, showing promising results in reducing incidence and recurrence. However, further research is necessary to optimize probiotic strains, dosages, and treatment protocols. This review underscores the need for a comprehensive understanding of the microbiological, immunological, and inflammatory factors involved in mastitis to develop effective prevention and treatment strategies.https://www.mdpi.com/2079-9721/13/6/176breastfeedingdysbiosisinflammationmastitis |
| spellingShingle | Mariarosaria Matera Chiara Maria Palazzi Alexander Bertuccioli Francesco Di Pierro Nicola Zerbinati Massimiliano Cazzaniga Aurora Gregoretti Ilaria Cavecchia The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis Diseases breastfeeding dysbiosis inflammation mastitis |
| title | The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis |
| title_full | The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis |
| title_fullStr | The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis |
| title_full_unstemmed | The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis |
| title_short | The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis |
| title_sort | role of targeted microbiota therapy in the prevention and management of puerperal mastitis |
| topic | breastfeeding dysbiosis inflammation mastitis |
| url | https://www.mdpi.com/2079-9721/13/6/176 |
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