Targeting oxidized phosphatidylcholines in SOD1-associated ALS: therapeutic potential of PC-OxPL-VecTab®

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Targeting oxidized phosphatidylcholines in SOD1-associated ALS: therapeutic potential of PC-OxPL-VecTab®

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration. Mutations in the superoxide dismutase 1 (SOD1) gene account for a significant fraction of familial ALS (fALS) cases. Oxidative stress and oxidized phosphatidylcholin...

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Bibliographic Details
Main Authors:	Andreia Gomes-Duarte, Sofia Pascoal, Rob Haselberg, Marina Sogorb-Gonzalez, Sander van Deventer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Neuroscience
Subjects:	amyotrophic lateral sclerosis superoxide dismutase 1 oxidized phosphatidylcholines gene therapy adeno-associated viruses
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1620181/full
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