Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational Study
Background: Hypothyroidism, affects approximately 11% of adults in India, leading to significant metabolic and cardiovascular dysfunction. This study aimed to assess the prevalence of asymptomatic cardiac anomalies in newly diagnosed hypothyroid patients using echocardiographic screening and to cont...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
|
| Series: | Journal of Nature and Science of Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jnsm.jnsm_146_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839639469754417152 |
|---|---|
| author | Jitender Sharma Vikas Kumar Anmol Sharma Aditya Puniyani |
| author_facet | Jitender Sharma Vikas Kumar Anmol Sharma Aditya Puniyani |
| author_sort | Jitender Sharma |
| collection | DOAJ |
| description | Background:
Hypothyroidism, affects approximately 11% of adults in India, leading to significant metabolic and cardiovascular dysfunction. This study aimed to assess the prevalence of asymptomatic cardiac anomalies in newly diagnosed hypothyroid patients using echocardiographic screening and to contextualize these findings within clinical practice.
Methodology:
A cross-sectional observational study was conducted over 10 years at a tertiary care hospital in Northern India, enrolling 200 patients with a primary diagnosis of hypothyroidism. Patients with secondary or subclinical hypothyroidism, preexisting cardiac conditions, or other comorbidities were excluded. Comprehensive clinical evaluations, blood tests, electrocardiogram, and 2D echocardiography were performed to detect systolic and diastolic dysfunction, pericardial effusion, and structural abnormalities. Statistical analysis was conducted using SPSS v22, employing descriptive metrics and proportions.
Results:
The mean age of the cohort was 37.65 years, with a female preponderance (77%). Common symptoms included weight gain (50%), lethargy, and menstrual irregularities (30%). Echocardiography revealed normal results in 15% of cases, while 26% demonstrated diastolic dysfunction, primarily moderate, and 20% exhibited pericardial effusion. Bradycardia and prehypertension were observed in 20% and 24% of patients, respectively, with interventricular septal thickening noted in 20 cases.
Conclusion:
This study underscores the high prevalence of subclinical cardiac anomalies in hypothyroidism, emphasizing the need for routine cardiovascular screening in newly diagnosed patients. Early detection and management can mitigate progression to overt cardiovascular morbidity. Future long-term studies are essential to evaluate these findings’ impact on mortality, morbidity, and overall clinical practice. |
| format | Article |
| id | doaj-art-2ac9c55bcfa7465a87f21a52c50ba41f |
| institution | Matheson Library |
| issn | 2589-627X 2589-6288 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Nature and Science of Medicine |
| spelling | doaj-art-2ac9c55bcfa7465a87f21a52c50ba41f2025-07-04T09:09:04ZengWolters Kluwer Medknow PublicationsJournal of Nature and Science of Medicine2589-627X2589-62882025-04-018215115410.4103/jnsm.jnsm_146_24Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational StudyJitender SharmaVikas KumarAnmol SharmaAditya PuniyaniBackground: Hypothyroidism, affects approximately 11% of adults in India, leading to significant metabolic and cardiovascular dysfunction. This study aimed to assess the prevalence of asymptomatic cardiac anomalies in newly diagnosed hypothyroid patients using echocardiographic screening and to contextualize these findings within clinical practice. Methodology: A cross-sectional observational study was conducted over 10 years at a tertiary care hospital in Northern India, enrolling 200 patients with a primary diagnosis of hypothyroidism. Patients with secondary or subclinical hypothyroidism, preexisting cardiac conditions, or other comorbidities were excluded. Comprehensive clinical evaluations, blood tests, electrocardiogram, and 2D echocardiography were performed to detect systolic and diastolic dysfunction, pericardial effusion, and structural abnormalities. Statistical analysis was conducted using SPSS v22, employing descriptive metrics and proportions. Results: The mean age of the cohort was 37.65 years, with a female preponderance (77%). Common symptoms included weight gain (50%), lethargy, and menstrual irregularities (30%). Echocardiography revealed normal results in 15% of cases, while 26% demonstrated diastolic dysfunction, primarily moderate, and 20% exhibited pericardial effusion. Bradycardia and prehypertension were observed in 20% and 24% of patients, respectively, with interventricular septal thickening noted in 20 cases. Conclusion: This study underscores the high prevalence of subclinical cardiac anomalies in hypothyroidism, emphasizing the need for routine cardiovascular screening in newly diagnosed patients. Early detection and management can mitigate progression to overt cardiovascular morbidity. Future long-term studies are essential to evaluate these findings’ impact on mortality, morbidity, and overall clinical practice.https://journals.lww.com/10.4103/jnsm.jnsm_146_24cardiovascular dysfunctiondiastolic dysfunctionechocardiographyhypothyroidismpericardial effusion |
| spellingShingle | Jitender Sharma Vikas Kumar Anmol Sharma Aditya Puniyani Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational Study Journal of Nature and Science of Medicine cardiovascular dysfunction diastolic dysfunction echocardiography hypothyroidism pericardial effusion |
| title | Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational Study |
| title_full | Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational Study |
| title_fullStr | Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational Study |
| title_full_unstemmed | Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational Study |
| title_short | Asymptomatic Cardiac Manifestations in Hypothyroidism- An Observational Study |
| title_sort | asymptomatic cardiac manifestations in hypothyroidism an observational study |
| topic | cardiovascular dysfunction diastolic dysfunction echocardiography hypothyroidism pericardial effusion |
| url | https://journals.lww.com/10.4103/jnsm.jnsm_146_24 |
| work_keys_str_mv | AT jitendersharma asymptomaticcardiacmanifestationsinhypothyroidismanobservationalstudy AT vikaskumar asymptomaticcardiacmanifestationsinhypothyroidismanobservationalstudy AT anmolsharma asymptomaticcardiacmanifestationsinhypothyroidismanobservationalstudy AT adityapuniyani asymptomaticcardiacmanifestationsinhypothyroidismanobservationalstudy |