Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells
ObjectiveTo explore the expression characteristics of BAIAP2L1 in cervical cancer (CC) and its regulatory role in tumor cell metastasis. MethodsThe correlation between BAIAP2L1 expression and clinical prognosis was analyzed by using a public database. GO pathway enrichment and clinicopathological co...
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Magazine House of Cancer Research on Prevention and Treatment
2025-06-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0951 |
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| author | Jueying ZHAO Zhuoying HAN Lulu FENG Chenlong WANG Li ZHANG Chao LUO Qilong WANG |
| author_facet | Jueying ZHAO Zhuoying HAN Lulu FENG Chenlong WANG Li ZHANG Chao LUO Qilong WANG |
| author_sort | Jueying ZHAO |
| collection | DOAJ |
| description | ObjectiveTo explore the expression characteristics of BAIAP2L1 in cervical cancer (CC) and its regulatory role in tumor cell metastasis. MethodsThe correlation between BAIAP2L1 expression and clinical prognosis was analyzed by using a public database. GO pathway enrichment and clinicopathological correlation analyses were conducted by employing R language. The effect of BAIAP2L1 knockdown on CC cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) were further investigated through gene silencing approaches. ResultsBAIAP2L1 expression was significantly upregulated in CC tissues (Padj <0.001) and it was identified as an independent risk factor for patient mortality (HR=2.808, P=0.03). Elevated BAIAP2L1 levels showed significant correlations with poor overall survival, advanced T/N stage, recurrence, and metastasis (all P<0.05). Functional enrichment analysis revealed its involvement in tumor metastasis-related pathways. The knockdown of BAIAP2L1 significantly attenuated CC cell proliferation, invasion, and migration and suppressed key EMT processes (all P<0.05). ConclusionBAIAP2L1 is overexpressed in CC tissues and associated with patient prognosis and metastasis. The targeted inhibition of BAIAP2L1 can effectively curb tumor progression. |
| format | Article |
| id | doaj-art-2aa27014e31c4b8e92abce28173f0bd3 |
| institution | Matheson Library |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-2aa27014e31c4b8e92abce28173f0bd32025-06-25T01:31:11ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-06-0152648149010.3971/j.issn.1000-8578.2025.24.095120240951Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer CellsJueying ZHAO0Zhuoying HAN1Lulu FENG2Chenlong WANG3Li ZHANG4Chao LUO5Qilong WANG6Department of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, ChinaDepartment of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, ChinaDepartment of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, ChinaDepartment of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, ChinaDepartment of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, ChinaDepartment of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, ChinaDepartment of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, ChinaObjectiveTo explore the expression characteristics of BAIAP2L1 in cervical cancer (CC) and its regulatory role in tumor cell metastasis. MethodsThe correlation between BAIAP2L1 expression and clinical prognosis was analyzed by using a public database. GO pathway enrichment and clinicopathological correlation analyses were conducted by employing R language. The effect of BAIAP2L1 knockdown on CC cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) were further investigated through gene silencing approaches. ResultsBAIAP2L1 expression was significantly upregulated in CC tissues (Padj <0.001) and it was identified as an independent risk factor for patient mortality (HR=2.808, P=0.03). Elevated BAIAP2L1 levels showed significant correlations with poor overall survival, advanced T/N stage, recurrence, and metastasis (all P<0.05). Functional enrichment analysis revealed its involvement in tumor metastasis-related pathways. The knockdown of BAIAP2L1 significantly attenuated CC cell proliferation, invasion, and migration and suppressed key EMT processes (all P<0.05). ConclusionBAIAP2L1 is overexpressed in CC tissues and associated with patient prognosis and metastasis. The targeted inhibition of BAIAP2L1 can effectively curb tumor progression.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0951baiap2l1cervical cancermetastasisprognosis |
| spellingShingle | Jueying ZHAO Zhuoying HAN Lulu FENG Chenlong WANG Li ZHANG Chao LUO Qilong WANG Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells Zhongliu Fangzhi Yanjiu baiap2l1 cervical cancer metastasis prognosis |
| title | Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells |
| title_full | Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells |
| title_fullStr | Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells |
| title_full_unstemmed | Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells |
| title_short | Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells |
| title_sort | clinical importance of baiap2l1 expression in cervical cancer and its effect on malignant phenotype of cervical cancer cells |
| topic | baiap2l1 cervical cancer metastasis prognosis |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0951 |
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