Analysis of follow-up data in large biobank cohorts: a review of methodology

Analysis of follow-up data in large biobank cohorts: a review of methodology

This study focuses on key methodological challenges in genome-wide association studies (GWAS) of biobank data with time-to-event outcomes, analyzed using the Cox proportional hazards (CPH) model. We address four primary issues: left-truncation of the data, computational inefficiency of standard mode...

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Bibliographic Details
Main Authors: Anastassia Kolde, Merli Koitmäe, Meelis Käärik, Märt Möls, Krista Fischer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Genetics
Subjects:
survival analysis
genome-wide association study
populationbased biobank data
martingale residuals
cox proportional hazards model
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1534726/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1534726/full

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