Antibacterial activity and mechanism of naphthoquine phosphate against ceftazidime-resistant Acinetobacter baumannii via cell membrane disruption and ROS induction

Antibacterial activity and mechanism of naphthoquine phosphate against ceftazidime-resistant Acinetobacter baumannii via cell membrane disruption and ROS induction

IntroductionDrug-resistant bacteria, particularly Acinetobacter baumannii, present a significant threat to global public health, highlighting the urgent need for novel antibacterial therapies. Drug repurposing has emerged as a promising strategy to accelerate therapeutic development by identifying n...

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Bibliographic Details
Main Authors: Yongtian Yuan, Liangliang Zhao, Zhuchun Bei, Baogang Wang, Dongna Zhang, Likun Xu, Jiahui Liu, Meng Lv, Qin Xu, Yabin Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
naphthoquine phosphate
Acinetobacter baumannii
antibacterial activity
cell membrane permeability
transcriptome analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1603462/full
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