STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS
The study for quantitation of TLR2, TLR4 and HBD-1 gene expression in urethral mucosal epithelium from women with chronic bacterial cystitis and healthy females. Materials and methods: RNA was extracted from the samples of urethral mucosa followed by RT-PCR. Results: increased expression of TLR2, TL...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2016-08-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/1072 |
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| author | O. A. Svitich L. V. Gankovskaya A. V. Berenshtein T. S. Perepanova E. M. Volkova |
| author_facet | O. A. Svitich L. V. Gankovskaya A. V. Berenshtein T. S. Perepanova E. M. Volkova |
| author_sort | O. A. Svitich |
| collection | DOAJ |
| description | The study for quantitation of TLR2, TLR4 and HBD-1 gene expression in urethral mucosal epithelium from women with chronic bacterial cystitis and healthy females. Materials and methods: RNA was extracted from the samples of urethral mucosa followed by RT-PCR. Results: increased expression of TLR2, TLR4 (respectively, 6.9-, 2.6-fold), along with 13.6-fold decrease in HBD-1 was revealed in women with chronic bacterial cystitis, as compared with appropriate parameters in normal women. Six months later, after combined therapy with autologous immunopeptide complex, TLR2, TLR4 и HBD1 expression levels proved to be near-normal in the patients, being similar to those in healthy females. Conclusion: Imbalanced expression of genes controlling innate immunity was revealed in urethral mucosa of the patients with chronic cystitis, thus increasing risk for urinary tract infections. |
| format | Article |
| id | doaj-art-28f3a80f4916433f93d69c847edab8e2 |
| institution | Matheson Library |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2016-08-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-28f3a80f4916433f93d69c847edab8e22025-08-04T14:30:34ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2016-08-0118546947410.15789/1563-0625-2016-5-469-474862STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITISO. A. Svitich0L. V. Gankovskaya1A. V. Berenshtein2T. S. Perepanova3E. M. Volkova4N. Pyrogov Russian National Research Medical University; I. Mechnikov Research Institute of Vaccines and SeraN. Pyrogov Russian National Research Medical UniversityN. Pyrogov Russian National Research Medical UniversityA. Lopatkin Research Institute of Urology and Interventional RadiologyA. Lopatkin Research Institute of Urology and Interventional RadiologyThe study for quantitation of TLR2, TLR4 and HBD-1 gene expression in urethral mucosal epithelium from women with chronic bacterial cystitis and healthy females. Materials and methods: RNA was extracted from the samples of urethral mucosa followed by RT-PCR. Results: increased expression of TLR2, TLR4 (respectively, 6.9-, 2.6-fold), along with 13.6-fold decrease in HBD-1 was revealed in women with chronic bacterial cystitis, as compared with appropriate parameters in normal women. Six months later, after combined therapy with autologous immunopeptide complex, TLR2, TLR4 и HBD1 expression levels proved to be near-normal in the patients, being similar to those in healthy females. Conclusion: Imbalanced expression of genes controlling innate immunity was revealed in urethral mucosa of the patients with chronic cystitis, thus increasing risk for urinary tract infections.https://www.mimmun.ru/mimmun/article/view/1072innate immunitymucosaurinary tract infectionstoll-like receptorsdefensins |
| spellingShingle | O. A. Svitich L. V. Gankovskaya A. V. Berenshtein T. S. Perepanova E. M. Volkova STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS Медицинская иммунология innate immunity mucosa urinary tract infections toll-like receptors defensins |
| title | STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS |
| title_full | STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS |
| title_fullStr | STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS |
| title_full_unstemmed | STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS |
| title_short | STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS |
| title_sort | studies of innate immunity parameters tlr2 tlr4 and hbd1 of uretheral mucous epithelium in chronic bacterial cystitis |
| topic | innate immunity mucosa urinary tract infections toll-like receptors defensins |
| url | https://www.mimmun.ru/mimmun/article/view/1072 |
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