The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives

The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives

Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10...

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Bibliographic Details
Main Authors: I. M. Bilay, E. O. Mihayluk, V. V. Parchenko, A. G. Kaplaushenko, A. I. Panasenko, E. G. Knysh
Format: Article
Language:English
Published: Zaporizhzhia State Medical and Pharmaceutical University 2014-08-01
Series:Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:
Pharmacological Actions
Drug Screening
Animal Experimental
Toxic Hepatitis
1
4-triazole
Online Access:http://pharmed.zsmu.edu.ua/article/view/26165/23623
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Summary:Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment. Сonclusion. Screening has shown that these class of compounds is promising for further research.
ISSN:2306-8094
2409-2932

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