Deciphering adenosine signaling in hepatocellular carcinoma: Pathways, prognostic models, and therapeutic implications

QR Code

Deciphering adenosine signaling in hepatocellular carcinoma: Pathways, prognostic models, and therapeutic implications

Hepatocellular carcinoma (HCC) is a highly lethal cancer due to its aggressive nature and poor prognosis. Adenosine, a key metabolic regulator in the tumor microenvironment (TME), plays a crucial role in cancer progression. In this review, we first described adenosine triphosphate adenosine metaboli...

Full description

Saved in:

Bibliographic Details
Main Authors:	Huihai Yang, Martina Mang Leng Lei, Longfei Xie, Yinuo Shou, Terence Kin Wah Lee
Format:	Article
Language:	English
Published:	Korean Association for the Study of the Liver 2025-07-01
Series:	Clinical and Molecular Hepatology
Subjects:	hepatocellular carcinoma adenosine receptors, purinergic signal transduction prognosis
Online Access:	http://e-cmh.org/upload/pdf/cmh-2024-1068.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Activation of Adenosine Phosphate Signaling Promotes Antitumor Immunity in Tumor Microenvironment and Facilitate Immunotherapy
by: Yantao Xu, et al.
Published: (2025-06-01)

Adenosine and adenosine receptors: a “double-edged sword” in cardiovascular system
by: Yongqi Qian, et al.
Published: (2025-07-01)

PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES
by: A. S. Golovkin, et al.
Published: (2018-06-01)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study
by: Maria Beatrice Morelli, et al.
Published: (2025-07-01)

<i>ENTPD1</i>, <i>NT5E</i>, <i>ADORA2A</i>, <i>FOXP3</i> and <i>RORγ</i> gene expression in peripheral blood of patients with ulcerative colitis
by: D. A. Atorin, et al.
Published: (2025-01-01)

Adenosine-dependent regulation of paracrine factors expression in human venous blood monocytes
by: S. V. Ryzhov, et al.
Published: (2011-06-01)

Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole
by: Taghreed Hazem Saber Alfakje, et al.
Published: (2022-12-01)

Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion
by: Jing‐Yan Cheng, et al.
Published: (2025-07-01)

Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia
by: Bianca Fagan Bissacotti, et al.
Published: (2025-06-01)

New Algorithm of Stress Echocardiography with Adenosine Triphosphate
by: N. Yu. Nelassov, et al.
Published: (2020-11-01)

Adenosine A<sub>2B</sub> Receptor Antagonism Interferes with TGF-β Cellular Signaling Through SMAD2/-3 and p65-Nf-κB in Podocytes and Protects from Phenotypical Transformation in Experimental Diabetic Glomerulopathy
by: Ignacio Arias, et al.
Published: (2025-06-01)

The Role of Adenosine A1 and A2a Receptors in Cerebral Blood Vessel Reactivity of Sprague Dawley Rats Exposed to Hyperbaric Oxygenation
by: Vedran Đambić, et al.
Published: (2025-07-01)

Pan-Immune-Inflammation Value as a Prognostic Biomarker for Hepatocellular Carcinoma Patients Undergoing Hepatectomy
by: Fu H, et al.
Published: (2025-05-01)

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins
by: Eloïse M. Paulet, et al.
Published: (2025-07-01)

Extracellular Vesicles and Purinergic Signaling in Alzheimer’s Disease—Joining Forces for Novel Therapeutic Approach
by: Julita Lewandowska, et al.
Published: (2025-05-01)

Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms
by: S. Kızıltepe, et al.
Published: (2025-07-01)

Effects of Cyclic Adenosine Monophosphate Nanoliposomes on Growth Performance, Gut Development and Microbiota of Broilers
by: Li Chen, et al.
Published: (2025-06-01)

Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular Carcinoma
by: Zhang J, et al.
Published: (2025-07-01)

Long-term results of liver transplantation for hepatocellular carcinoma
by: M. Sh. Khubutia, et al.
Published: (2018-08-01)

THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
by: N. T. Vatutin, et al.
Published: (2018-02-01)

Estimation of Nitric Oxide, Malondialdehyde, and Adenosine Deaminase in Serum of Hypertensive Patients and Normotensive Individuals in Erbil City
by: Gulzar I. Ibrahim, et al.
Published: (2019-05-01)

Study of the Effectiveness of Drugs Based on Molecular Complexes of Adenosine-polymer on the Model of Thermal Burn
by: E. D. Semivelichenko, et al.
Published: (2022-09-01)

Prognostic utility of the global leadership initiative on malnutrition criteria in predicting outcomes after hepatectomy for hepatocellular carcinoma: a multicenter, retrospective study
by: Yaohao Liang, et al.
Published: (2025-06-01)

Fermentation Kinetics and Gene Expression Patterns in Adenosine Biosynthesis by <i>Bacillus subtilis</i>
by: Gengxuan Yan, et al.
Published: (2025-07-01)

Myocardial perfusion in patients with diabetes mellitus according to stress CMR with adenosine triphosphate
by: A. I. Pivovarova, et al.
Published: (2024-03-01)

Hernandezine induces autophagic cell death in hepatocellular carcinoma cells via the AMPK/mTOR signaling pathway
by: WANG Jun, HU Gangfeng, GAO Weichen, WANG Lubing
Published: (2025-03-01)

New prognostic model for liver transplantation outcomes in hepatocellular carcinoma
by: S. E. Voskanyan, et al.
Published: (2024-09-01)

The expression level and clinical significance of lncRNA X91348 in hepatocellular carcinoma
by: Zhen Zeng, et al.
Published: (2019-12-01)

Adenosine Deaminase and Systemic Immune Inflammatory Index—A Biomarker Duet Signature of Pulmonary Tuberculosis Severity
by: Ioan Anton Arghir, et al.
Published: (2025-06-01)

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy
by: O. A. Gromova, et al.
Published: (2025-02-01)

Survival Benefit of Adjuvant Treatment with Huaier Granules Plus Lenvatinib in Hepatocellular Carcinoma Patients with Tumors Greater Than 5 cm After Radical Hepatectomy
by: Liu C, et al.
Published: (2025-07-01)

FABP4 suppresses proliferation and invasion of hepatocellular carcinoma cells and predicts a poor prognosis for hepatocellular carcinoma
by: Cheng‐Qian Zhong, et al.
Published: (2018-06-01)

Clinical value of controlling nutritional status scores in patients with hepatocellular carcinoma
by: Rongqiang Liu, et al.
Published: (2025-06-01)

Safety and efficacy of elapegademase in patients with adenosine deaminase deficiency: A multicenter, open‐label, single‐arm, phase 3, and postmarketing clinical study
by: Masafumi Onodera, et al.
Published: (2023-07-01)

A novel vasculogenic mimicry-related nomogram predicts prognosis in hepatocellular carcinoma
by: Yun Zhong, et al.
Published: (2025-07-01)

RAR-Based Prognostic Model for Predicting Overall Survival in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study
by: Tan M, et al.
Published: (2025-07-01)

Osteopenic occult vertebral fracture is associated with poor oncological outcome in patients with hepatocellular carcinoma after hepatic resection
by: Koichiro Haruki, et al.
Published: (2025-07-01)

Combined extensive liver resections in patients with locally advanced hepatocellular cancer – clinical cases
by: D. V. Sidorov, et al.
Published: (2020-06-01)

Molecular Subtyping of Hepatocellular Carcinoma via Lysosome-Related Genes for Prognosis and Therapy Prediction
by: Yao Y, et al.
Published: (2025-07-01)

Prognostic Value of the SII-PNI Score in Unresectable HCC Treated with Transcatheter Arterial Chemoembolization Combined with Lenvatinib and PD-1 Inhibitors
by: Wei SM, et al.
Published: (2025-06-01)