Artificial neural network guided optimization of tenofovir and Cyanovirin-N multipurpose preventive hydrogel formulation developed using the Box Behnken design model

Artificial neural network guided optimization of tenofovir and Cyanovirin-N multipurpose preventive hydrogel formulation developed using the Box Behnken design model

Tenofovir (TNF) is an antiretroviral drug that has being used as a topical microbicide to prevent human immunodeficiency virus transmission (HIV). Cyanovirin-N (CV-N) is a lectin protein that can bind to the HIV envelope glycoprotein and inhibit viral entry. The combination of TNF and CV-N may have...

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Bibliographic Details
Main Authors: Karamot O. Oyediran, Ibilola M. Cardoso-Daodu, Peace Ofonabasi Bassey, Deborah A. Ogundemuren, Ridwan Muhammed, Olusola E. Ojo, Andrew N. Amenaghawon, Chukwuemeka P. Azubuike, Rachna Agarwal, Kondoru Haritha, Margaret O. Ilomunaya
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Pharmaceutical Science Advances
Subjects:
Box Behnken design
Artificial neural network
Hydrogels
Cyanovirin-N
Tenofovir
Flux
Online Access:http://www.sciencedirect.com/science/article/pii/S2773216925000170
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http://www.sciencedirect.com/science/article/pii/S2773216925000170

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