In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines
Ferruginol, tanshinones and carnosol are considered privileged natural products due to their demonstrated diverse biological activities with relevance to cancer research. Globally, cancer continues to be a major contributor to mortality rates, making these compounds potentially valuable molecular sc...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/1420-3049/30/12/2529 |
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| author | Miguel A. González-Cardenete William E. Mendoza-Hernández Sydney L. Lawson Fatima Rivas |
| author_facet | Miguel A. González-Cardenete William E. Mendoza-Hernández Sydney L. Lawson Fatima Rivas |
| author_sort | Miguel A. González-Cardenete |
| collection | DOAJ |
| description | Ferruginol, tanshinones and carnosol are considered privileged natural products due to their demonstrated diverse biological activities with relevance to cancer research. Globally, cancer continues to be a major contributor to mortality rates, making these compounds potentially valuable molecular scaffolds for further development as potential anticancer agents. In this work, a focused library of ferruginol, tanshinone IIA, and carnosol analogues was studied to examine their effectiveness against various solid tumor models. The compounds were efficiently synthesized from either methyl 12-hydroxy-dehydroabietate or 12-hydroxydehydroabietylamine in 1–3 step processes with good chemical yields. The compounds that were synthesized underwent a methodical evaluation using multiple biological tests (including viability assays, clonogenic assays, and mitochondrial membrane polarization measurements) to determine their ability to inhibit in vitro the growth of three breast cancer cell linages. It was determined that while most compounds exhibited biological activity, compounds <b>10</b> and <b>11</b> demonstrated significant efficacy against triple negative breast cancer cells. These compounds continue to show promising biological activity, suggesting that additional studies to understand their mechanisms of action would be valuable. |
| format | Article |
| id | doaj-art-26f60082548c47fd856a0a2d8decb49c |
| institution | Matheson Library |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-26f60082548c47fd856a0a2d8decb49c2025-06-25T14:13:28ZengMDPI AGMolecules1420-30492025-06-013012252910.3390/molecules30122529In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell LinesMiguel A. González-Cardenete0William E. Mendoza-Hernández1Sydney L. Lawson2Fatima Rivas3Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avda. de los Naranjos s/n, 46022 Valencia, SpainInstituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avda. de los Naranjos s/n, 46022 Valencia, SpainDepartment of Chemistry, Louisiana State University, 133 Choppin Hall, Baton Rouge, LA 70803, USADepartment of Chemistry, Louisiana State University, 133 Choppin Hall, Baton Rouge, LA 70803, USAFerruginol, tanshinones and carnosol are considered privileged natural products due to their demonstrated diverse biological activities with relevance to cancer research. Globally, cancer continues to be a major contributor to mortality rates, making these compounds potentially valuable molecular scaffolds for further development as potential anticancer agents. In this work, a focused library of ferruginol, tanshinone IIA, and carnosol analogues was studied to examine their effectiveness against various solid tumor models. The compounds were efficiently synthesized from either methyl 12-hydroxy-dehydroabietate or 12-hydroxydehydroabietylamine in 1–3 step processes with good chemical yields. The compounds that were synthesized underwent a methodical evaluation using multiple biological tests (including viability assays, clonogenic assays, and mitochondrial membrane polarization measurements) to determine their ability to inhibit in vitro the growth of three breast cancer cell linages. It was determined that while most compounds exhibited biological activity, compounds <b>10</b> and <b>11</b> demonstrated significant efficacy against triple negative breast cancer cells. These compounds continue to show promising biological activity, suggesting that additional studies to understand their mechanisms of action would be valuable.https://www.mdpi.com/1420-3049/30/12/2529abietanecytotoxicitybreast cancer cellstanshinonecarnosolferruginol |
| spellingShingle | Miguel A. González-Cardenete William E. Mendoza-Hernández Sydney L. Lawson Fatima Rivas In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines Molecules abietane cytotoxicity breast cancer cells tanshinone carnosol ferruginol |
| title | In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines |
| title_full | In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines |
| title_fullStr | In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines |
| title_full_unstemmed | In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines |
| title_short | In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines |
| title_sort | in vitro effect of ferruginol tanshinone and carnosol analogues on the proliferation of three breast cancer cell lines |
| topic | abietane cytotoxicity breast cancer cells tanshinone carnosol ferruginol |
| url | https://www.mdpi.com/1420-3049/30/12/2529 |
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