SEARCH FOR CELL VOLUME SENSORS: AN UPDATE
Cell volume changes affect a plethora of cellular functions including macromolecular synthesis and catabolism, cell proliferation, differentiation and death. Because of these critical roles, cells regulate their volume with <1% accuracy via compensatory mechanisms termed regulatory volume inc...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2013-08-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/364 |
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| _version_ | 1839570068143341568 |
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| author | S. N. Orlov R. Grygorszyk |
| author_facet | S. N. Orlov R. Grygorszyk |
| author_sort | S. N. Orlov |
| collection | DOAJ |
| description | Cell volume changes affect a plethora of cellular functions including macromolecular synthesis and catabolism, cell proliferation, differentiation and death. Because of these critical roles, cells regulate their volume with <1% accuracy via compensatory mechanisms termed regulatory volume increase and regulatory volume decrease. Our review focuses on recent advances in understanding the molecular origin of up-stream sensors triggering cellular responses to volume perturbations. The analysis demonstrates a major role of cytoplasmic hydrogel as well as the crosstalk of polyphosphoinositides and twodimensional cytoskeleton (membrane carcass) in cell volume sensing. |
| format | Article |
| id | doaj-art-26d40a2ce44e4c8b9cd8b5bd1a8b28e8 |
| institution | Matheson Library |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2013-08-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-26d40a2ce44e4c8b9cd8b5bd1a8b28e82025-08-04T16:45:36ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-08-011241323356SEARCH FOR CELL VOLUME SENSORS: AN UPDATES. N. Orlov0R. Grygorszyk1Centre de recherche, Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, PQ, Canada; Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, MoscowCentre de recherche, Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, PQCell volume changes affect a plethora of cellular functions including macromolecular synthesis and catabolism, cell proliferation, differentiation and death. Because of these critical roles, cells regulate their volume with <1% accuracy via compensatory mechanisms termed regulatory volume increase and regulatory volume decrease. Our review focuses on recent advances in understanding the molecular origin of up-stream sensors triggering cellular responses to volume perturbations. The analysis demonstrates a major role of cytoplasmic hydrogel as well as the crosstalk of polyphosphoinositides and twodimensional cytoskeleton (membrane carcass) in cell volume sensing.https://bulletin.ssmu.ru/jour/article/view/364cell volumemembrane stretchcytoskeletonbiogel |
| spellingShingle | S. N. Orlov R. Grygorszyk SEARCH FOR CELL VOLUME SENSORS: AN UPDATE Бюллетень сибирской медицины cell volume membrane stretch cytoskeleton biogel |
| title | SEARCH FOR CELL VOLUME SENSORS: AN UPDATE |
| title_full | SEARCH FOR CELL VOLUME SENSORS: AN UPDATE |
| title_fullStr | SEARCH FOR CELL VOLUME SENSORS: AN UPDATE |
| title_full_unstemmed | SEARCH FOR CELL VOLUME SENSORS: AN UPDATE |
| title_short | SEARCH FOR CELL VOLUME SENSORS: AN UPDATE |
| title_sort | search for cell volume sensors an update |
| topic | cell volume membrane stretch cytoskeleton biogel |
| url | https://bulletin.ssmu.ru/jour/article/view/364 |
| work_keys_str_mv | AT snorlov searchforcellvolumesensorsanupdate AT rgrygorszyk searchforcellvolumesensorsanupdate |