Green synthesized Zingiber officinale-ZnO nanoparticles: anticancer efficacy against 3D breast cancer model
Aim: ZnO NPs were prepared via green synthesis utilizing Zingiber Officinale.Methodology: Physical characterization and biological activity were performed against 2D, and 3D spheroids MCF-7 cell lines.Results: The NPs exhibited 188.9, 175.7 and 171.2 nm size with charge of -8.2, -11.7 and -9.7 mV fo...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2024.2419806 |
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| Summary: | Aim: ZnO NPs were prepared via green synthesis utilizing Zingiber Officinale.Methodology: Physical characterization and biological activity were performed against 2D, and 3D spheroids MCF-7 cell lines.Results: The NPs exhibited 188.9, 175.7 and 171.2 nm size with charge of -8.2, -11.7 and -9.7 mV for the 2%, 3% and 4% formulations. XRD confirmed a wurtzite hexagonal phase. FTIR spectra showed Zn-O stretching vibrations. The 2%, 3% and 4% formulations presented IC50 values of 14.7, 26.2 and 47 μg/ml, respectively, with complete destruction of MCF-7 spheroids. Elevated TNF-α levels suggested an inflammatory-mediated mechanism of action.Conclusion: 2% Zingiber officinale-derived ZnO NPs showed antitumor potential against deserving further mechanistic and in vivo explorations. |
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| ISSN: | 2056-5623 |