Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension
Copper (Cu) and iron (Fe) are essential trace elements that are involved in normal human metabolic processes. Disruption of their homeostasis contributes to disease pathogenesis through mechanisms such as cuproptosis and ferroptosis. Cuproptosis targets lipoylated proteins to disrupt mitochondrial r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1611449/full |
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| author | Yan Yang Lu Liang Wanjuan Pei Yinhui Sun |
| author_facet | Yan Yang Lu Liang Wanjuan Pei Yinhui Sun |
| author_sort | Yan Yang |
| collection | DOAJ |
| description | Copper (Cu) and iron (Fe) are essential trace elements that are involved in normal human metabolic processes. Disruption of their homeostasis contributes to disease pathogenesis through mechanisms such as cuproptosis and ferroptosis. Cuproptosis targets lipoylated proteins to disrupt mitochondrial respiration, whereas ferroptosis is driven by lipid peroxidation. These processes may independently or interactively exacerbate pulmonary hypertension (PH), a condition characterized by progressive pulmonary vascular remodeling, clinical manifestations of dyspnea, right-sided heart failure, and high mortality, via oxidative stress, metabolic reprogramming, and other mechanisms. This review systematically elucidates: (1) the updated molecular mechanisms of cuproptosis/ferroptosis, (2) research evidence for their roles in PH, and (3) synergistic crosstalk in different subtypes of PH progression. We propose that coordination and regulation of the crosstalk network between cuproptosis and ferroptosis may represent a novel therapeutic strategy for pulmonary vascular remodeling. |
| format | Article |
| id | doaj-art-23f57f99efbd436b97963f7c14a37e11 |
| institution | Matheson Library |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-23f57f99efbd436b97963f7c14a37e112025-06-26T05:28:07ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.16114491611449Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertensionYan YangLu LiangWanjuan PeiYinhui SunCopper (Cu) and iron (Fe) are essential trace elements that are involved in normal human metabolic processes. Disruption of their homeostasis contributes to disease pathogenesis through mechanisms such as cuproptosis and ferroptosis. Cuproptosis targets lipoylated proteins to disrupt mitochondrial respiration, whereas ferroptosis is driven by lipid peroxidation. These processes may independently or interactively exacerbate pulmonary hypertension (PH), a condition characterized by progressive pulmonary vascular remodeling, clinical manifestations of dyspnea, right-sided heart failure, and high mortality, via oxidative stress, metabolic reprogramming, and other mechanisms. This review systematically elucidates: (1) the updated molecular mechanisms of cuproptosis/ferroptosis, (2) research evidence for their roles in PH, and (3) synergistic crosstalk in different subtypes of PH progression. We propose that coordination and regulation of the crosstalk network between cuproptosis and ferroptosis may represent a novel therapeutic strategy for pulmonary vascular remodeling.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1611449/fullferroptosiscuproptosispulmonary hypertensionoxidative stressmetabolic reprogrammingmitochondrial dysfunction |
| spellingShingle | Yan Yang Lu Liang Wanjuan Pei Yinhui Sun Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension Frontiers in Cardiovascular Medicine ferroptosis cuproptosis pulmonary hypertension oxidative stress metabolic reprogramming mitochondrial dysfunction |
| title | Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension |
| title_full | Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension |
| title_fullStr | Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension |
| title_full_unstemmed | Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension |
| title_short | Interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension |
| title_sort | interaction of ferroptosis and cuproptosis in the perspective of pulmonary hypertension |
| topic | ferroptosis cuproptosis pulmonary hypertension oxidative stress metabolic reprogramming mitochondrial dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1611449/full |
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