LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation

LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation

ABSTRACT Coxsackievirus B5 (CVB5) is a primary causative agent of hand, foot, and mouth disease (HFMD), and some cases are also associated with severe complications through invasion of the central nervous system, resulting in death. Currently, there are no specific antiviral drugs or effective vacci...

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Bibliographic Details
Main Authors: Jiayu Zhang, Jing Li, Yonghan Luo, Timothy J. Mahony, Jingru Gao, Yanchun Wang, Xiaotao Yang, Fan Yang, Xia Ou, Jihong Zhang, Heng Yang, Wei Chen
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSphere
Subjects:
coxsackievirus B5 (CVB5)
long non-coding RNAs (lncRNAs)
LINC2781; GTPase-activating protein SH3 domain-binding protein 2 (G3BP2)
STAT1
Online Access:https://journals.asm.org/doi/10.1128/msphere.00062-25
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