Single-cell sequencing revealed the recurrence causes of ETV6:RUNX1 fusion-positive B-ALL in children

Single-cell sequencing revealed the recurrence causes of ETV6:RUNX1 fusion-positive B-ALL in children

Objective: The ETV6RUNX1 fusion is the most common genetic abnormality in childhood B-cell acute lymphoblastic leukemia (B-ALL), yet nearly 50 % of relapses occur in patients initially classified as low-risk with this alteration. This study aimed to unravel the underlying pathways driving relapse in...

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Main Authors: Guotao Guan, Xiuxiu Wang, Xiuxin Li, Qi Wang, Xiuli Li, Xiaojun Sun, Liying Liu, Yunfeng Lu, Bingju Liu, Xinyu Li, Ping Zhao, Fei Gao, Lijun Chen, Lihua Zhao, Yunpeng Dai
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Molecular and Cellular Probes
Subjects:
B-ALL
Recurrence
ETV6:RUNX1 fusion
scRNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S0890850825000349
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