Relationship between Metformin and Frailty Syndrome in Elderly People with Type 2 Diabetes
Aim: to explore the possibility of metformin protective effect on frailty syndrome. Methods: this was a case control study conducted in subjects’ ≥60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Dia...
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| Main Authors: | , , , |
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| Format: | Article |
| Sprog: | engelsk |
| Udgivet: |
Interna Publishing
2016-05-01
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| Serier: | Acta Medica Indonesiana |
| Online adgang: | https://www.actamedindones.org/index.php/ijim/article/view/87 |
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| Summary: | Aim: to explore the possibility of metformin protective effect on frailty syndrome. Methods: this was a case control study conducted in subjects’ ≥60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Diagnosis of frailty was established using the FI-40 item criteria. Statistical analysis was done with chi-square method for bivariate and logistic regression method in multivariate analysis, all data was accompanied with 95% confidence interval. Results: frailty syndrome was found in 25% of subjects (n=59), with median age of 72 years old (SD 6.27) and median of FI-40 item score was 0.18 (SD 0.085). Metformin was found to have a significant relationship with frailty syndrome in the elderly diabetics, which retained significant value after multivariate analysis (adjusted OR 0.043; 95% CI 0.019-0.099; p<0.001). Conclusion: metformin was shown to have protective effect against frailty syndrome in elderly diabetics.
Key words: frailty, diabetes mellitus, metformin, elderly.
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| ISSN: | 0125-9326 2338-2732 |