The mysterious link between migraine aura and migraine headache.
Migraine aura - manifesting as transient, neurological disturbances - presents a complex and unresolved relationship with migraine headache. Cortical spreading depolarization (SD), recognized as the mechanism underlying aura symptoms, has been shown to trigger head pain through activation of trigemi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-06-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3003168 |
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| _version_ | 1839651479072276480 |
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| author | Anders Hougaard Cenk Ayata K C Brennan Arn M J M van den Maagdenberg Messoud Ashina |
| author_facet | Anders Hougaard Cenk Ayata K C Brennan Arn M J M van den Maagdenberg Messoud Ashina |
| author_sort | Anders Hougaard |
| collection | DOAJ |
| description | Migraine aura - manifesting as transient, neurological disturbances - presents a complex and unresolved relationship with migraine headache. Cortical spreading depolarization (SD), recognized as the mechanism underlying aura symptoms, has been shown to trigger head pain through activation of trigeminal nociceptors in animal models. However, recent clinical data challenge the notion that aura causes migraine headache in patients. In this Essay, we critically examine the pathophysiology of migraine aura and migraine headache, exploring evidence from clinical observations, (genetic) mouse models, and pharmacological studies. We also discuss the role of SD, the trigeminovascular system, and the impact of pharmacological agents that both trigger and treat migraine attacks. Our essay highlights the complexities and conflicting data surrounding the interplay between aura and headache, emphasizing the need for further research to unravel this mystery and improve therapeutic strategies for individuals with migraine. |
| format | Article |
| id | doaj-art-22f1a87d0bcf4501a2f5c94f3a538e10 |
| institution | Matheson Library |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-22f1a87d0bcf4501a2f5c94f3a538e102025-06-26T05:30:35ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852025-06-01236e300316810.1371/journal.pbio.3003168The mysterious link between migraine aura and migraine headache.Anders HougaardCenk AyataK C BrennanArn M J M van den MaagdenbergMessoud AshinaMigraine aura - manifesting as transient, neurological disturbances - presents a complex and unresolved relationship with migraine headache. Cortical spreading depolarization (SD), recognized as the mechanism underlying aura symptoms, has been shown to trigger head pain through activation of trigeminal nociceptors in animal models. However, recent clinical data challenge the notion that aura causes migraine headache in patients. In this Essay, we critically examine the pathophysiology of migraine aura and migraine headache, exploring evidence from clinical observations, (genetic) mouse models, and pharmacological studies. We also discuss the role of SD, the trigeminovascular system, and the impact of pharmacological agents that both trigger and treat migraine attacks. Our essay highlights the complexities and conflicting data surrounding the interplay between aura and headache, emphasizing the need for further research to unravel this mystery and improve therapeutic strategies for individuals with migraine.https://doi.org/10.1371/journal.pbio.3003168 |
| spellingShingle | Anders Hougaard Cenk Ayata K C Brennan Arn M J M van den Maagdenberg Messoud Ashina The mysterious link between migraine aura and migraine headache. PLoS Biology |
| title | The mysterious link between migraine aura and migraine headache. |
| title_full | The mysterious link between migraine aura and migraine headache. |
| title_fullStr | The mysterious link between migraine aura and migraine headache. |
| title_full_unstemmed | The mysterious link between migraine aura and migraine headache. |
| title_short | The mysterious link between migraine aura and migraine headache. |
| title_sort | mysterious link between migraine aura and migraine headache |
| url | https://doi.org/10.1371/journal.pbio.3003168 |
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