IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL

IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL

The article presents experimental data on regulatory effect of neutrophilokine helper fractions on the macrophage (Mph) functional activity in the course of antiplague immunity formation. It has revealed that these fractions content biologically active, low-molecular weight peptides. They stimulate...

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Bibliographic Details
Main Authors: G. I. Vasilieva, I. A. Ivanova, I. A. Bespalova, N. D. Omeltchenko, A. K. Kiseleva, E. P. Doroschenko, S. Yu. Tyukavkina
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
Subjects:
regulatory peptide fractions
neutrophils
macrophages
functional activity
Online Access:https://www.mimmun.ru/mimmun/article/view/131
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Summary:The article presents experimental data on regulatory effect of neutrophilokine helper fractions on the macrophage (Mph) functional activity in the course of antiplague immunity formation. It has revealed that these fractions content biologically active, low-molecular weight peptides. They stimulate Mph killing activity by increasing phagosome-lysosome fusion, thus boosting transformation of monocytes to Mph, and causing redistribution of macrophage subpopulations in the total cellular pool. The helper effect of neutrophilokine fractions upon functional activity of MPh is more pronounced during secondary immune response.
ISSN:1563-0625
2313-741X

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