3-Bromopyruvate Impairs Mitochondrial Function in <i>Trypanosoma cruzi</i>

3-Bromopyruvate Impairs Mitochondrial Function in <i>Trypanosoma cruzi</i>

<i>Trypanosoma cruzi</i> is a kinetoplastid parasite and etiological agent of Chagas disease. Given the significant morbidity and mortality rates of this parasitic disease, possible treatment alternatives need to be studied. 3-Bromopyruvate (3-BrPA) is a synthetic analog of pyruvate that...

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Main Authors: Rafaella Oliveira da Costa, Davi Barreto-Campos, Juliana Barbosa-de-Barros, Giovanna Frechiani, Luiz Fernando Carvalho-Kelly, Ayra Diandra Carvalho-de-Araújo, José Roberto Meyer-Fernandes, Claudia Fernanda Dick
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pathogens
Subjects:
Chagas disease
energy metabolism
3-bromopyruvate
Online Access:https://www.mdpi.com/2076-0817/14/7/631
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