THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS
Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Atherosclerosis is the main cause of death and disability in developed countries, while in developing countries the incidence of this pathology is growing rapidly. Advances...
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SINAPS LLC
2018-12-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/848 |
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| author | T. V. Kozhanova E. V. Neudakhin S. S. Zhilina T. I. Mescheryakova A. A. Abramov E. N. Lukash A. G. Prityko |
| author_facet | T. V. Kozhanova E. V. Neudakhin S. S. Zhilina T. I. Mescheryakova A. A. Abramov E. N. Lukash A. G. Prityko |
| author_sort | T. V. Kozhanova |
| collection | DOAJ |
| description | Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Atherosclerosis is the main cause of death and disability in developed countries, while in developing countries the incidence of this pathology is growing rapidly. Advances in techniques of molecular genetics have revealed that genetic polymorphisms significantly influence susceptibility to atherosclerotic vascular diseases. A large number of candidate genes, genetic polymorphisms and susceptibility loci associated with atherosclerotic diseases have been identified in recent years and their number is rapidly increasing. In recent years, there is significant interest in identifying additional factors of genetic risk for atherosclerosis. In recent years, a large number of genetic studies have been carried out to prove the genetic effect on the atherosclerotic process. Rapid progress in the sequencing of the human genome and molecular genetic methods have helped in the definition of susceptibility loci and associated candidate genes with atherosclerosis and concomitant diseases. The association of a large number of susceptibility genes with atherosclerosis reflects the enormous complexity of the disease. Multiple factors, including endothelial dysfunction, lipid metabolism defects, inflammation and immune responses, oxidative stress, cell proliferation, tissue remodeling and hemostatic defects are involved in the pathogenesis of atherosclerosis. In this review we focus and discuss on some of the major candidate genes and genetic polymorphisms associated with human atherosclerotic vascular diseases. |
| format | Article |
| id | doaj-art-22a3a2d7f99d4b2a8ace2d18f15edbc1 |
| institution | Matheson Library |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-22a3a2d7f99d4b2a8ace2d18f15edbc12025-08-04T14:09:46ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642018-12-018640741710.20514/2226-67042018-8-6-407-417702THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIST. V. Kozhanova0E. V. Neudakhin1S. S. Zhilina2T. I. Mescheryakova3A. A. Abramov4E. N. Lukash5A. G. Prityko6St. Luka Scientific and Practical Center of Specialized Medical Care for Children, Department of Health; Pirogov Russian National Research Medical UniversitySt. Luka Scientific and Practical Center of Specialized Medical Care for Children, Department of Health; Pirogov Russian National Research Medical UniversitySt. Luka Scientific and Practical Center of Specialized Medical Care for Children, Department of Health; Pirogov Russian National Research Medical UniversitySt. Luka Scientific and Practical Center of Specialized Medical Care for Children, Department of HealthSt. Luka Scientific and Practical Center of Specialized Medical Care for Children, Department of HealthSt. Luka Scientific and Practical Center of Specialized Medical Care for Children, Department of HealthSt. Luka Scientific and Practical Center of Specialized Medical Care for Children, Department of Health; Pirogov Russian National Research Medical UniversityAtherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Atherosclerosis is the main cause of death and disability in developed countries, while in developing countries the incidence of this pathology is growing rapidly. Advances in techniques of molecular genetics have revealed that genetic polymorphisms significantly influence susceptibility to atherosclerotic vascular diseases. A large number of candidate genes, genetic polymorphisms and susceptibility loci associated with atherosclerotic diseases have been identified in recent years and their number is rapidly increasing. In recent years, there is significant interest in identifying additional factors of genetic risk for atherosclerosis. In recent years, a large number of genetic studies have been carried out to prove the genetic effect on the atherosclerotic process. Rapid progress in the sequencing of the human genome and molecular genetic methods have helped in the definition of susceptibility loci and associated candidate genes with atherosclerosis and concomitant diseases. The association of a large number of susceptibility genes with atherosclerosis reflects the enormous complexity of the disease. Multiple factors, including endothelial dysfunction, lipid metabolism defects, inflammation and immune responses, oxidative stress, cell proliferation, tissue remodeling and hemostatic defects are involved in the pathogenesis of atherosclerosis. In this review we focus and discuss on some of the major candidate genes and genetic polymorphisms associated with human atherosclerotic vascular diseases.https://www.medarhive.ru/jour/article/view/848atherosclerosisgenepolymorphismsgenetic testing |
| spellingShingle | T. V. Kozhanova E. V. Neudakhin S. S. Zhilina T. I. Mescheryakova A. A. Abramov E. N. Lukash A. G. Prityko THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS Архивъ внутренней медицины atherosclerosis gene polymorphisms genetic testing |
| title | THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS |
| title_full | THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS |
| title_fullStr | THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS |
| title_full_unstemmed | THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS |
| title_short | THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS |
| title_sort | genetic susceptibility to atherosclerosis |
| topic | atherosclerosis gene polymorphisms genetic testing |
| url | https://www.medarhive.ru/jour/article/view/848 |
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