ENDOTHELIAL GLYCOCALYX DEGRADATION IN CEREBRAL EDEMA: PROMISING OPPORTUNITIES FOR INTENSIVE CARE
A literature review was conducted on the role of the endothelial glycocalyx (eGC) in the pathogenesis of cerebral edema (CE) and the management methods within the context of intensive care. The search for relevant information was carried out using the PubMed, ScienceDirect, and eLibrary databases, e...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Avicenna Tajik State Medical University
2025-07-01
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| Series: | Паёми Сино |
| Subjects: | |
| Online Access: | https://doi.org/10.25005/2074-0581-2025-27-2-416-427 |
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| Summary: | A literature review was conducted on the role of the endothelial glycocalyx (eGC) in the pathogenesis of cerebral edema (CE) and the management methods within the context of intensive care. The search for relevant information was carried out using the PubMed, ScienceDirect, and eLibrary databases, employing the following keywords: "cerebral edema", "glycocalyx", "methods of drug correction", "pathogenesis", and "intensive care". The inclusion criteria for thisreview were studiesthat explored markers of eGC degradation in CE and investigationsinto the effects of various methods
and drugs on eGC integrity. Articles older than ten years were excluded from the review.
CE is a significant and potentially life-threatening complication associated with various neurological diseases and injuries. Despite advancesin intensive care, mortality rates for this condition remain high, and treatment options are often limited. One of the primary pathological mechanisms underlying CE is the disruption of the blood-brain barrier, resulting in increased vascular permeability.
Emerging evidence suggests that the eGC, a unique glycoprotein layer on the endothelial surface, plays a crucial role in maintaining the barrier properties of the vascular wall. Damage to the eGC in various pathological conditions contributes to the development of vasogenic edema, triggering inflammation and coagulation. Investigating the molecular mechanisms underlying eGC damage and developing strategies for its protection and restoration are crucial for enhancing outcomes in cases of CE. This area of research presents new opportunities for intensive care, complementing existing treatment approaches. Therefore, studying the role of the eGC in the pathogenesis of cerebral edema and exploring methods for its management are both relevant and clinically significant endeavors. |
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| ISSN: | 2074-0581 2959-6327 |