Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome
Aim. To study the associations of allelic variants of the CYP2C19 gene with atherosclerotic lesions of the coronary arteries in patients with acute coronary syndrome (ACS) in the North of Siberia (Surgut) and in large cities of the Siberian Federal Okrug (SFO).Material and methods. During the study...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2018-11-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2804 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839576804330831872 |
|---|---|
| author | K. Yu. Nikolaev I. A. Urvantseva K. Yu. Batueva K. A. Apartsin A. V. Gorokhova V. I. Ganyukov N. A. Kochergin E. M. Zelenskaya G. I. Lifshitz |
| author_facet | K. Yu. Nikolaev I. A. Urvantseva K. Yu. Batueva K. A. Apartsin A. V. Gorokhova V. I. Ganyukov N. A. Kochergin E. M. Zelenskaya G. I. Lifshitz |
| author_sort | K. Yu. Nikolaev |
| collection | DOAJ |
| description | Aim. To study the associations of allelic variants of the CYP2C19 gene with atherosclerotic lesions of the coronary arteries in patients with acute coronary syndrome (ACS) in the North of Siberia (Surgut) and in large cities of the Siberian Federal Okrug (SFO).Material and methods. During the study 296 patients with ACS were examined at admission to cardiology hospitals in large cities of the North (Surgut, 114 patients) and SFO (Irkutsk and Kemerovo, 182 patients). All patients underwent coronary angiography and genetic research (identification of CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles).Results. In patients with ACS living in the North of Russia allelic variant CYP2C19*17 (*17/*17) is positively associated with the severity of lesion of left coronary artery (LCA) (χ2=9,81; p=0,002), as well as with at least 50% stenosis, more than 70% lesion of the proximal or middle part of the three main arteries, or more than 50% lesion of LCA trunk (χ2 =6,52; p=0,011), and previous myocardial infarction (χ2=8,15; p=0,004). Among patients with ACS living in cities of the Siberian Federal Okrug, the allelic variant CYP2C19*17 (*17/*17) is directly associated with diabetes mellitus (χ2=5,48; p=0,019) and less than 45% left ventricular ejection fraction (χ2=4,20; p=0,040). Regression analysis showed that in patients with ACS living in the northern region of Russia, only the allelic variant CYP2C19*17 (*17/*17) correlated with at least 50% stenosis of LCA trunk (Exp (B): 11,623, 95% CI: 1,893; 71,342; p=0,008). It did not correlate with the male sex, age, smoking and diabetes (p>0,05).Conclusion. The results show the presence of direct associations of CYP2C19*17 alleles with prognostically unfavorable coronary atherosclerosis in ACS patients living in the North of Siberia. |
| format | Article |
| id | doaj-art-21ee14a3bf9b4d9b8f36e16a75ff9ecf |
| institution | Matheson Library |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2018-11-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-21ee14a3bf9b4d9b8f36e16a75ff9ecf2025-08-04T13:00:18Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202018-11-01010283210.15829/1560-4071-2018-10-28-322441Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndromeK. Yu. Nikolaev0I. A. Urvantseva1K. Yu. Batueva2K. A. Apartsin3A. V. Gorokhova4V. I. Ganyukov5N. A. Kochergin6E. M. Zelenskaya7G. I. Lifshitz8SRI of Therapy and Prevention Medicine — branch of SD RAS; Novosibirsk State UniversitySurgut State UniversitySurgut State UniversityIrkutsk Scientific Center of SD RAS; Irkutskaya Oblast Clinical Hospital of the “Sign of Honour” AwardIrkutsk Scientific Center of SD RAS; Irkutskaya Oblast Clinical Hospital of the “Sign of Honour” AwardResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesInstitute of Chemical Biology and Fundamental Medicine of SD RASNovosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of SD RASAim. To study the associations of allelic variants of the CYP2C19 gene with atherosclerotic lesions of the coronary arteries in patients with acute coronary syndrome (ACS) in the North of Siberia (Surgut) and in large cities of the Siberian Federal Okrug (SFO).Material and methods. During the study 296 patients with ACS were examined at admission to cardiology hospitals in large cities of the North (Surgut, 114 patients) and SFO (Irkutsk and Kemerovo, 182 patients). All patients underwent coronary angiography and genetic research (identification of CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles).Results. In patients with ACS living in the North of Russia allelic variant CYP2C19*17 (*17/*17) is positively associated with the severity of lesion of left coronary artery (LCA) (χ2=9,81; p=0,002), as well as with at least 50% stenosis, more than 70% lesion of the proximal or middle part of the three main arteries, or more than 50% lesion of LCA trunk (χ2 =6,52; p=0,011), and previous myocardial infarction (χ2=8,15; p=0,004). Among patients with ACS living in cities of the Siberian Federal Okrug, the allelic variant CYP2C19*17 (*17/*17) is directly associated with diabetes mellitus (χ2=5,48; p=0,019) and less than 45% left ventricular ejection fraction (χ2=4,20; p=0,040). Regression analysis showed that in patients with ACS living in the northern region of Russia, only the allelic variant CYP2C19*17 (*17/*17) correlated with at least 50% stenosis of LCA trunk (Exp (B): 11,623, 95% CI: 1,893; 71,342; p=0,008). It did not correlate with the male sex, age, smoking and diabetes (p>0,05).Conclusion. The results show the presence of direct associations of CYP2C19*17 alleles with prognostically unfavorable coronary atherosclerosis in ACS patients living in the North of Siberia.https://russjcardiol.elpub.ru/jour/article/view/2804acute coronary syndromecoronary artery atherosclerosisallelic variants of cyp2c19 genenorthern region of russia |
| spellingShingle | K. Yu. Nikolaev I. A. Urvantseva K. Yu. Batueva K. A. Apartsin A. V. Gorokhova V. I. Ganyukov N. A. Kochergin E. M. Zelenskaya G. I. Lifshitz Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome Российский кардиологический журнал acute coronary syndrome coronary artery atherosclerosis allelic variants of cyp2c19 gene northern region of russia |
| title | Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome |
| title_full | Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome |
| title_fullStr | Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome |
| title_full_unstemmed | Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome |
| title_short | Regional aspects of associations of the CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome |
| title_sort | regional aspects of associations of the cyp2c19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome |
| topic | acute coronary syndrome coronary artery atherosclerosis allelic variants of cyp2c19 gene northern region of russia |
| url | https://russjcardiol.elpub.ru/jour/article/view/2804 |
| work_keys_str_mv | AT kyunikolaev regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT iaurvantseva regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT kyubatueva regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT kaapartsin regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT avgorokhova regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT viganyukov regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT nakochergin regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT emzelenskaya regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome AT gilifshitz regionalaspectsofassociationsofthecyp2c19genepolymorphismwithcoronaryatherosclerosisinacutecoronarysyndrome |