Acneiform Eruptions Caused by Lithium Treatment May Be Related to <i>Demodex</i> Mites (Prostigmata: Demodecidae): A Hypothesis

Acneiform eruptions are a common adverse effect of lithium treatment that may impact adherence. It is not clear why lithium may worsen these lesions and treatment has focused on traditional treatments for acne. <i>Demodex</i> mites are known to commensurably exist in a large fraction of...

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Bibliographic Details
Main Authors: Rif S. El-Mallakh, Masoud Doroodgar, Mehak Pahwa, Omar H. A. Elsayed
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biology
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Online Access:https://www.mdpi.com/2079-7737/14/6/605
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Summary:Acneiform eruptions are a common adverse effect of lithium treatment that may impact adherence. It is not clear why lithium may worsen these lesions and treatment has focused on traditional treatments for acne. <i>Demodex</i> mites are known to commensurably exist in a large fraction of humans and are known to cause dermatologic conditions in a minority of individuals. An association with acneiform eruptions is well documented but is generally believed to not be causative. We present a hypothesis that lithium treatment may alter the environment of <i>Demodex</i> mites in a fashion that may increase their propensity to cause disease. If that is accurate, treatment with acaricidal agents may be an additional option.
ISSN:2079-7737