Ferroptosis: a double-edged sword that enhances radiation sensitivity and facilitates radiation-induced injury in tumors

Ferroptosis: a double-edged sword that enhances radiation sensitivity and facilitates radiation-induced injury in tumors

Cell death is a crucial mechanism by which radiotherapy eliminates tumor cells. Ferroptosis, characterized by intracellular iron overload and lipid peroxidation, represents a distinct form of programmed cell death. Recent research has demonstrated that numerous malignant tumors exhibit high sensitiv...

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Bibliographic Details
Main Authors: Yang Liu, Jianhao Zhan, Jisheng Wang, Xiaoping Zeng, Shanshan Liu, Le Huang, Liyan Niu, Chengpeng Sun, Zijun Ding, Yan Xing, Zhengyu Zhou, Xiaoying Li, Qing Li, Hongmei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
radiotherapy
ferroptosis
radiotherapy sensitivity
radiation-induced injury
pharmacotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1591172/full
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