ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus

ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus

Summary: Organ shortage remains a critical challenge in India’s transplant landscape, despite established deceased donor organ transplantation (DDOT) programmes. Many potentially viable organs from brain-dead deceased donors (DBDs) are discarded due to uncertainties surrounding donor suitability in...

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Main Authors: Manish R. Balwani, Vivek B. Kute, Jigar Shrimali, Bharat G. Jagiasi, Pradip Kumar Bhattacharya, Amit Pasari, Manoj Gumber, Sanjeev Gulati, Raj Kanwar Yadav, Shankar Prasad Nagaraju, Gomathy Narasimhan, Natarajan Gopalkrishnan, Divyesh Engineer, Tushar Dighe, Jamal Rizvi, Sanjay P. Kolte, Vishal Vasant Ramteke, Nishant Shantanu Deshpande, Priyanka Tolani, Georgi Abraham, Abhijit Patil, Anurag Gupta, Dhananjai Agarwal, Dinesh Khullar, Narayan Prasad, Pratik Das, Radhika Krishna Patil, Ravi Mohanka, Sandeep Mahajan, Sourabh Sharma, Subho Banerjee, Vinant Bhargava, Jyoti Patodia, Arpita Ray Chaudhury, Aneesh Srivastava
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:The Lancet Regional Health - Southeast Asia
Subjects:
Deceased donor
Kidney transplant
Acute kidney injury
Infections
End-stage organ failure
Online Access:http://www.sciencedirect.com/science/article/pii/S277236822500099X
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Summary:Summary: Organ shortage remains a critical challenge in India’s transplant landscape, despite established deceased donor organ transplantation (DDOT) programmes. Many potentially viable organs from brain-dead deceased donors (DBDs) are discarded due to uncertainties surrounding donor suitability in specific clinical scenarios. To address this gap, the Indian Society of Organ Transplantation (ISOT) convened a panel of national experts to develop a Delphi consensus statement aimed at guiding transplant professionals on the feasibility of organ donation from DBDs, particularly in complex or marginal donor situations. This position statement presents 19 consensus recommendations based on real-world clinical contexts such as extremes of age, acute kidney injury, infections (including HCV, HBV, HIV, tuberculosis, and tropical diseases), malignancy, diabetes, hypertension, and various surgical anomalies. The guidance is grounded in available literature, registry data, and extensive clinical experience, with the aim of expanding the DBD donor pool across Asia and improving access to transplantation for patients with end-stage organ failure. The consensus does not function as a formal clinical guideline but rather as a practical reference tool, acknowledging the limitations in India-specific data and the contextual differences from Western transplant settings. It encourages critical care and transplant teams to perform structured assessments of organ viability, apply ethical principles, and pursue informed consent in line with local regulations.
ISSN:2772-3682

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