Maternal Gut Inflammation Aggravates Acute Liver Failure Through Facilitating Ferroptosis via Altering Gut Microbial Metabolism in Offspring

Maternal Gut Inflammation Aggravates Acute Liver Failure Through Facilitating Ferroptosis via Altering Gut Microbial Metabolism in Offspring

Abstract Microbial transmission from mother to infant is important for offspring microbiome formation and health. However, it is unclear whether maternal gut inflammation (MGI) during lactation influences mother‐to‐infant microbial transmission and offspring microbiota and disease susceptibility. In...

Full description

Saved in:
Bibliographic Details
Main Authors: Caijun Zhao, Lijuan Bao, Ruping Shan, Yihong Zhao, Keyi Wu, Shan Shang, Haiqi Li, Yi Liu, Ke Chen, Naisheng Zhang, Cong Ye, Xiaoyu Hu, Yunhe Fu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
acute liver failure
ferroptosis
gut microbiota
indole‐3‐acetic acid
maternal gut inflammation
offspring
Online Access:https://doi.org/10.1002/advs.202411985
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Microbial transmission from mother to infant is important for offspring microbiome formation and health. However, it is unclear whether maternal gut inflammation (MGI) during lactation influences mother‐to‐infant microbial transmission and offspring microbiota and disease susceptibility. In this study, it is found that MGI during lactation altered the gut microbiota of suckling pups by shaping the maternal microbiota in the gut and mammary glands. MGI‐induced changes in the gut microbiota of suckling pups lasted into adulthood, resulting in the exacerbation of acute liver failure (ALF) caused by acetaminophen (APAP) in offspring. Specifically, MGI reduced the abundance of Lactobacillus reuteri (L. reuteri) and its metabolite indole‐3‐acetic acid (IAA) level in adult offspring. L. reuteri and IAA alleviated ALF in mice by promoting intestinal IL‐22 production. Mechanistically, IL‐22 limits APAP‐induced excessive oxidative stress and ferroptosis by activating STAT3. The intestinal abundances of L. reuteri and IAA are inversely associated with the progression of patients with ALF. Overall, the study reveals the role of MGI in mother‐to‐infant microbial transmission and disease development in offspring, highlighting potential strategies for intervention in ALF based on the IAA‐IL‐22‐STAT3 axis.
ISSN:2198-3844

Similar Items