The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs
Abstract Cerebral ischemia–reperfusion (I/R) injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke (AIS). It has been found that the brain renin–angiotensin system, especially the angiotensin II type 1 receptor (AT1R) pathway, plays a significant r...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-06-01
|
| Series: | Neuroprotection |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/nep3.45 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839627105682325504 |
|---|---|
| author | Shuhan Huang Meng Zhang |
| author_facet | Shuhan Huang Meng Zhang |
| author_sort | Shuhan Huang |
| collection | DOAJ |
| description | Abstract Cerebral ischemia–reperfusion (I/R) injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke (AIS). It has been found that the brain renin–angiotensin system, especially the angiotensin II type 1 receptor (AT1R) pathway, plays a significant role in cerebral I/R injury. This pathway is involved in processes such as oxidative stress, neuroinflammation, apoptosis, and it affects cerebrovascular autoregulation and the maintenance of blood–brain barrier. AT1R blocker (ARB), widely used as an antihypertensive agent, has demonstrated stroke prevention capabilities in numerous prospective studies, independent of its antihypertensive characteristics. Studies focusing on neurological diseases like Alzheimer's disease, Parkinson's disease, and cognitive impairment have confirmed that ARBs exhibit neuroprotective effects and aid in improving neurological functions. Preclinical studies have shown that ARBs can reduce infarct volume and brain edema, inhibit multiple signaling pathways associated with I/R injury, restore energy levels in damaged brain regions, and rescue the penumbra by promoting neovascularization in cerebral I/R models. These findings suggest that ARBs have potential to become a novel category of neuroprotecting agents for clinical treatment of AIS. Therefore, this review primarily provides a theoretical foundation and practical evidence for the future clinical utilization of ARBs as neuroprotective agents following reperfusion therapy for AIS. It outlines the role of cerebral I/R injury through the AT1R pathway and highlights the research progress made on ARBs in I/R models. |
| format | Article |
| id | doaj-art-1f2db2e25f9c4bea93c6731c7724f3af |
| institution | Matheson Library |
| issn | 2770-7296 2770-730X |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuroprotection |
| spelling | doaj-art-1f2db2e25f9c4bea93c6731c7724f3af2025-07-16T14:40:44ZengWileyNeuroprotection2770-72962770-730X2024-06-012210011910.1002/nep3.45The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBsShuhan Huang0Meng Zhang1Department of Neurology and Center for Clinical Neuroscience, Daping Hospital Army Medical University Chongqing ChinaDepartment of Neurology and Center for Clinical Neuroscience, Daping Hospital Army Medical University Chongqing ChinaAbstract Cerebral ischemia–reperfusion (I/R) injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke (AIS). It has been found that the brain renin–angiotensin system, especially the angiotensin II type 1 receptor (AT1R) pathway, plays a significant role in cerebral I/R injury. This pathway is involved in processes such as oxidative stress, neuroinflammation, apoptosis, and it affects cerebrovascular autoregulation and the maintenance of blood–brain barrier. AT1R blocker (ARB), widely used as an antihypertensive agent, has demonstrated stroke prevention capabilities in numerous prospective studies, independent of its antihypertensive characteristics. Studies focusing on neurological diseases like Alzheimer's disease, Parkinson's disease, and cognitive impairment have confirmed that ARBs exhibit neuroprotective effects and aid in improving neurological functions. Preclinical studies have shown that ARBs can reduce infarct volume and brain edema, inhibit multiple signaling pathways associated with I/R injury, restore energy levels in damaged brain regions, and rescue the penumbra by promoting neovascularization in cerebral I/R models. These findings suggest that ARBs have potential to become a novel category of neuroprotecting agents for clinical treatment of AIS. Therefore, this review primarily provides a theoretical foundation and practical evidence for the future clinical utilization of ARBs as neuroprotective agents following reperfusion therapy for AIS. It outlines the role of cerebral I/R injury through the AT1R pathway and highlights the research progress made on ARBs in I/R models.https://doi.org/10.1002/nep3.45acute ischemic strokeangiotensin II type 1 receptor blockerischemia–reperfusion injuryneuroinflammationoxidative stress |
| spellingShingle | Shuhan Huang Meng Zhang The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs Neuroprotection acute ischemic stroke angiotensin II type 1 receptor blocker ischemia–reperfusion injury neuroinflammation oxidative stress |
| title | The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs |
| title_full | The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs |
| title_fullStr | The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs |
| title_full_unstemmed | The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs |
| title_short | The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs |
| title_sort | role of angiotensin ii type 1 receptor pathway in cerebral ischemia reperfusion injury implications for the neuroprotective effect of arbs |
| topic | acute ischemic stroke angiotensin II type 1 receptor blocker ischemia–reperfusion injury neuroinflammation oxidative stress |
| url | https://doi.org/10.1002/nep3.45 |
| work_keys_str_mv | AT shuhanhuang theroleofangiotensiniitype1receptorpathwayincerebralischemiareperfusioninjuryimplicationsfortheneuroprotectiveeffectofarbs AT mengzhang theroleofangiotensiniitype1receptorpathwayincerebralischemiareperfusioninjuryimplicationsfortheneuroprotectiveeffectofarbs AT shuhanhuang roleofangiotensiniitype1receptorpathwayincerebralischemiareperfusioninjuryimplicationsfortheneuroprotectiveeffectofarbs AT mengzhang roleofangiotensiniitype1receptorpathwayincerebralischemiareperfusioninjuryimplicationsfortheneuroprotectiveeffectofarbs |