Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virus

Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virus

Porcine reproductive and respiratory syndrome (PRRS) is recognized as one of the most infectious viral diseases of swine. Although Cluster of differentiation 163 (CD163) is identified as an essential receptor for mediating PRRS virus (PRRSV) infection, the important residues involved in infection on...

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Bibliographic Details
Main Authors: Kui XU, Yan-rong ZHOU, Hai-tao SHANG, Chang-jiang XU, Ran TAO, Wan-jun HAO, Sha-sha LIU, Yu-lian MU, Shao-bo XIAO, Kui LI
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-07-01
Series:Journal of Integrative Agriculture
Subjects:
pigs
porcine alveolar macrophages
dual-sgRNA
homology-directed repair
PRRSV
CD163
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311922002830
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