The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment
Aim. To determine the heart failure (HF) risk in patients with hypertension (HTN) and high adherence to treatment, depending on the blood concentration of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and gene polymorphism.Material and methods. The study included 232 patients with HTN wit...
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«FIRMA «SILICEA» LLC
2020-04-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3708 |
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| author | N. A. Koziolova A. I. Chernyavina |
| author_facet | N. A. Koziolova A. I. Chernyavina |
| author_sort | N. A. Koziolova |
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| description | Aim. To determine the heart failure (HF) risk in patients with hypertension (HTN) and high adherence to treatment, depending on the blood concentration of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and gene polymorphism.Material and methods. The study included 232 patients with HTN without a verified diagnosis of HF. The mean age was 46,13±8,21 years. Patients were evaluated for genotypes by following markers: AGT Thr174Met rs4762, GNB3 C825T rs5443, MTHFR C677T rs1801133, MTRR Ile22Met rs1801394, ApoE Cys130Arg rs 429358, PPARα G/C rs425377. We also assessed ejection fraction, diastolic function and left ventricular mass index by echocardiography and determined NT-proBNP blood levels. Patients were divided into two groups depending on the NT-proBNP concentration. The group 1 consisted of 64 (27,6%) patients with NT-proBNP >125 pg/ml, the group 2 — 168 (72,4%) patients with NT-proBNP <125 pg/ml.Results. Among patients with NT-proBNP >125 pg/ml, the most significant was the C/T genotype of MTHFR C677T polymorphism (rs1801133), 95% confidence interval (CI) for the odds ratio (OR) and relative risk (RR) of HF was 4,82 and 3,29, respectively (95% CI for OR=2,24-10,60; for OR=1,80-6,39). The A/G and G/G genotypes of the MTRR Ile22Met polymorphism (rs1801394) were statistically significant. The probability of HF with the A/G genotype of the MTRR gene increased by more than 2 times (OR=2,32, 95% CI=1,15-4,64), and the OR of its development was 1,77 (95% CI=1,11-2,69). The probability of HF with the G/G genotype increased more than 3 times (OR=3,65, 95% CI=1,37-9,76), and the OR of its development was 2,20 (95% CI=1,25-3,27). Correlation analysis revealed a direct relationship between the NTproBNP levels and polymorphism of the MTHFR (r=0,47; p<0,005) and MTRR (r=0,33; p<0,05) genes.Conclusion. In patients with HTN and high adherence to treatment, the HF risk with an Nt-proBNP >125 pg/ml depends on genetic determinism. Candidate genes for the HF in HTN patients with high adherence to treatment are the genotypes C/T of MTHFR C677T polymorphism (rs1801133), and A/G and G/G of MTRR Ile22Met polymorphism (rs1801394). |
| format | Article |
| id | doaj-art-1eca8929c2094e9c81f6e62f0fa32acf |
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| language | Russian |
| publishDate | 2020-04-01 |
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| spelling | doaj-art-1eca8929c2094e9c81f6e62f0fa32acf2025-08-04T13:00:22Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202020-04-0125310.15829/1560-4071-2020-3-37082881The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatmentN. A. Koziolova0A. I. Chernyavina1E. A. Wagner Perm State Medical UniversityE. A. Wagner Perm State Medical UniversityAim. To determine the heart failure (HF) risk in patients with hypertension (HTN) and high adherence to treatment, depending on the blood concentration of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and gene polymorphism.Material and methods. The study included 232 patients with HTN without a verified diagnosis of HF. The mean age was 46,13±8,21 years. Patients were evaluated for genotypes by following markers: AGT Thr174Met rs4762, GNB3 C825T rs5443, MTHFR C677T rs1801133, MTRR Ile22Met rs1801394, ApoE Cys130Arg rs 429358, PPARα G/C rs425377. We also assessed ejection fraction, diastolic function and left ventricular mass index by echocardiography and determined NT-proBNP blood levels. Patients were divided into two groups depending on the NT-proBNP concentration. The group 1 consisted of 64 (27,6%) patients with NT-proBNP >125 pg/ml, the group 2 — 168 (72,4%) patients with NT-proBNP <125 pg/ml.Results. Among patients with NT-proBNP >125 pg/ml, the most significant was the C/T genotype of MTHFR C677T polymorphism (rs1801133), 95% confidence interval (CI) for the odds ratio (OR) and relative risk (RR) of HF was 4,82 and 3,29, respectively (95% CI for OR=2,24-10,60; for OR=1,80-6,39). The A/G and G/G genotypes of the MTRR Ile22Met polymorphism (rs1801394) were statistically significant. The probability of HF with the A/G genotype of the MTRR gene increased by more than 2 times (OR=2,32, 95% CI=1,15-4,64), and the OR of its development was 1,77 (95% CI=1,11-2,69). The probability of HF with the G/G genotype increased more than 3 times (OR=3,65, 95% CI=1,37-9,76), and the OR of its development was 2,20 (95% CI=1,25-3,27). Correlation analysis revealed a direct relationship between the NTproBNP levels and polymorphism of the MTHFR (r=0,47; p<0,005) and MTRR (r=0,33; p<0,05) genes.Conclusion. In patients with HTN and high adherence to treatment, the HF risk with an Nt-proBNP >125 pg/ml depends on genetic determinism. Candidate genes for the HF in HTN patients with high adherence to treatment are the genotypes C/T of MTHFR C677T polymorphism (rs1801133), and A/G and G/G of MTRR Ile22Met polymorphism (rs1801394).https://russjcardiol.elpub.ru/jour/article/view/3708gene polymorphismhypertensionnatriuretic peptides |
| spellingShingle | N. A. Koziolova A. I. Chernyavina The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment Российский кардиологический журнал gene polymorphism hypertension natriuretic peptides |
| title | The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment |
| title_full | The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment |
| title_fullStr | The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment |
| title_full_unstemmed | The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment |
| title_short | The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment |
| title_sort | relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment |
| topic | gene polymorphism hypertension natriuretic peptides |
| url | https://russjcardiol.elpub.ru/jour/article/view/3708 |
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