Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis
Abstract Arterial thrombosis is a severe cardiovascular condition associated with high mortality and disability rates. Traditional pharmacological thrombolytic therapies, however, are limited by a narrow therapeutic window, short drug half‐lives, restricted therapeutic effectiveness, and the risk of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-07-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202501134 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839640512543326208 |
|---|---|
| author | Ying Li Qi Xiang Yan Zhang Fuxue Luo Yunfang Wu Haitao Ran Yang Cao |
| author_facet | Ying Li Qi Xiang Yan Zhang Fuxue Luo Yunfang Wu Haitao Ran Yang Cao |
| author_sort | Ying Li |
| collection | DOAJ |
| description | Abstract Arterial thrombosis is a severe cardiovascular condition associated with high mortality and disability rates. Traditional pharmacological thrombolytic therapies, however, are limited by a narrow therapeutic window, short drug half‐lives, restricted therapeutic effectiveness, and the risk of hemorrhagic complications. Moreover, the unique biological microenvironment of arterial thrombosis is characterized by high shear stress and an inflammatory milieu rich in reactive oxygen species (ROS), resulting in a relatively high recurrence rate. To address these challenges, a mechanical biomimetic nanocomposite MPB‐NO‐UK@PM is developed by doping sodium nitroprusside, a nitric oxide (NO) donor, into mesoporous Prussian blue (MPB) nanoparticles to form MPB‐NO, which is then loaded with urokinase (UK) and coated with platelet membranes (PM). The nanocomposite exhibits excellent thrombus‐targeting ability and enhances thrombolytic efficacy through synergistic photothermal and pharmacological, while simultaneously reducing the risk of bleeding. The released NO induces antiplatelet aggregation effects, while Prussian blue effectively scavenges ROS and inflammatory cytokines, thereby preventing thrombus recurrence. Additionally, the nanocomposite possesses superior photoacoustic imaging capabilities, enabling visualization of thrombus diagnosis and treatment. This therapeutic approach represents a novel pathway for the multidimensional and efficient management of arterial thrombosis. |
| format | Article |
| id | doaj-art-1e9f1b2f5db7417e94e23c99b6f48877 |
| institution | Matheson Library |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-1e9f1b2f5db7417e94e23c99b6f488772025-07-03T12:38:31ZengWileyAdvanced Science2198-38442025-07-011225n/an/a10.1002/advs.202501134Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial ThrombosisYing Li0Qi Xiang1Yan Zhang2Fuxue Luo3Yunfang Wu4Haitao Ran5Yang Cao6Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy Ultrasound Department of the Second Affiliated Hospital Institute of Ultrasound Imaging State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing 400016 ChinaChongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy Ultrasound Department of the Second Affiliated Hospital Institute of Ultrasound Imaging State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing 400016 ChinaChongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy Ultrasound Department of the Second Affiliated Hospital Institute of Ultrasound Imaging State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing 400016 ChinaChongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy Ultrasound Department of the Second Affiliated Hospital Institute of Ultrasound Imaging State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing 400016 ChinaChongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy Ultrasound Department of the Second Affiliated Hospital Institute of Ultrasound Imaging State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing 400016 ChinaChongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy Ultrasound Department of the Second Affiliated Hospital Institute of Ultrasound Imaging State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing 400016 ChinaChongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy Ultrasound Department of the Second Affiliated Hospital Institute of Ultrasound Imaging State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing 400016 ChinaAbstract Arterial thrombosis is a severe cardiovascular condition associated with high mortality and disability rates. Traditional pharmacological thrombolytic therapies, however, are limited by a narrow therapeutic window, short drug half‐lives, restricted therapeutic effectiveness, and the risk of hemorrhagic complications. Moreover, the unique biological microenvironment of arterial thrombosis is characterized by high shear stress and an inflammatory milieu rich in reactive oxygen species (ROS), resulting in a relatively high recurrence rate. To address these challenges, a mechanical biomimetic nanocomposite MPB‐NO‐UK@PM is developed by doping sodium nitroprusside, a nitric oxide (NO) donor, into mesoporous Prussian blue (MPB) nanoparticles to form MPB‐NO, which is then loaded with urokinase (UK) and coated with platelet membranes (PM). The nanocomposite exhibits excellent thrombus‐targeting ability and enhances thrombolytic efficacy through synergistic photothermal and pharmacological, while simultaneously reducing the risk of bleeding. The released NO induces antiplatelet aggregation effects, while Prussian blue effectively scavenges ROS and inflammatory cytokines, thereby preventing thrombus recurrence. Additionally, the nanocomposite possesses superior photoacoustic imaging capabilities, enabling visualization of thrombus diagnosis and treatment. This therapeutic approach represents a novel pathway for the multidimensional and efficient management of arterial thrombosis.https://doi.org/10.1002/advs.202501134arterial thrombolysisnitric oxidephotoacoustic imagingphotothermal therapyPrussian blue nanocompositereactive oxygen species |
| spellingShingle | Ying Li Qi Xiang Yan Zhang Fuxue Luo Yunfang Wu Haitao Ran Yang Cao Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis Advanced Science arterial thrombolysis nitric oxide photoacoustic imaging photothermal therapy Prussian blue nanocomposite reactive oxygen species |
| title | Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis |
| title_full | Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis |
| title_fullStr | Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis |
| title_full_unstemmed | Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis |
| title_short | Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis |
| title_sort | mechanical biomimetic nanocomposites for multidimensional treatment of arterial thrombosis |
| topic | arterial thrombolysis nitric oxide photoacoustic imaging photothermal therapy Prussian blue nanocomposite reactive oxygen species |
| url | https://doi.org/10.1002/advs.202501134 |
| work_keys_str_mv | AT yingli mechanicalbiomimeticnanocompositesformultidimensionaltreatmentofarterialthrombosis AT qixiang mechanicalbiomimeticnanocompositesformultidimensionaltreatmentofarterialthrombosis AT yanzhang mechanicalbiomimeticnanocompositesformultidimensionaltreatmentofarterialthrombosis AT fuxueluo mechanicalbiomimeticnanocompositesformultidimensionaltreatmentofarterialthrombosis AT yunfangwu mechanicalbiomimeticnanocompositesformultidimensionaltreatmentofarterialthrombosis AT haitaoran mechanicalbiomimeticnanocompositesformultidimensionaltreatmentofarterialthrombosis AT yangcao mechanicalbiomimeticnanocompositesformultidimensionaltreatmentofarterialthrombosis |