Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy
Effective mild-temperature photothermal therapy (MTPTT) requires photothermal agents with high photothermal conversion efficiency (PCE) and balanced fluorescence quantum yield to enable efficient tumor treatment while minimizing damage to surrounding healthy tissues. In this study, we designed donor...
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Tsinghua University Press
2025-06-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.26599/NBE.2025.9290120 |
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| author | Xuan Sun Zuyuan Zhang Chunbai Xiang Tianhe Qiao Xin Wang Gongcheng Ma Dan Ding |
| author_facet | Xuan Sun Zuyuan Zhang Chunbai Xiang Tianhe Qiao Xin Wang Gongcheng Ma Dan Ding |
| author_sort | Xuan Sun |
| collection | DOAJ |
| description | Effective mild-temperature photothermal therapy (MTPTT) requires photothermal agents with high photothermal conversion efficiency (PCE) and balanced fluorescence quantum yield to enable efficient tumor treatment while minimizing damage to surrounding healthy tissues. In this study, we designed donor–acceptor–donor structured dyes, 4,4’-((6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline) (IT-STPA) and 4,4’-((6,7-di(furan-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline) (IT-OTPA), featuring furan-modified thiadiazolo-quinoxaline for near-infrared–II (NIR-II) fluorescence imaging and enhanced PCE. The furan and thiophene modifications promoted aggregation-induced emission, resulting in strong fluorescence emission (1 000–1 400 nm) while maintaining a high PCE of 48.5%. IT-OTPA was encapsulated into nanoparticles for improved aqueous dispersion and combined with the HSP70 inhibitor apoptozole (APZ) to form OTAPZ nanoparticles. The efficacy of this combination was evaluated both in vitro and in vivo, showing efficient tumor targeting and effective MTPTT under NIR laser irradiation. This study presents a promising approach for enhancing MTPTT through balanced photothermal and fluorescence properties, offering new possibilities for cancer treatment. |
| format | Article |
| id | doaj-art-1e6311b9e6f54be5b81e93dd18e2a0fe |
| institution | Matheson Library |
| issn | 2097-3837 2150-5578 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tsinghua University Press |
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| series | Nano Biomedicine and Engineering |
| spelling | doaj-art-1e6311b9e6f54be5b81e93dd18e2a0fe2025-07-04T02:34:00ZengTsinghua University PressNano Biomedicine and Engineering2097-38372150-55782025-06-0117224826210.26599/NBE.2025.9290120Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal TherapyXuan Sun0Zuyuan Zhang1Chunbai Xiang2Tianhe Qiao3Xin Wang4Gongcheng Ma5Dan Ding6The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer and Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, ChinaThe First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer and Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, ChinaKey Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University Chengdu 610064, ChinaThe First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer and Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, ChinaThe First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer and Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, ChinaSchool of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, ChinaFrontiers Science Center for New Organic Matter, Engineering & Smart Sensing Interdisciplinary Science Center, MOE Key Laboratory of Bioactive Materials, and college of Life Sciences, Nankai University, Tianjin 300350, ChinaEffective mild-temperature photothermal therapy (MTPTT) requires photothermal agents with high photothermal conversion efficiency (PCE) and balanced fluorescence quantum yield to enable efficient tumor treatment while minimizing damage to surrounding healthy tissues. In this study, we designed donor–acceptor–donor structured dyes, 4,4’-((6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline) (IT-STPA) and 4,4’-((6,7-di(furan-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline) (IT-OTPA), featuring furan-modified thiadiazolo-quinoxaline for near-infrared–II (NIR-II) fluorescence imaging and enhanced PCE. The furan and thiophene modifications promoted aggregation-induced emission, resulting in strong fluorescence emission (1 000–1 400 nm) while maintaining a high PCE of 48.5%. IT-OTPA was encapsulated into nanoparticles for improved aqueous dispersion and combined with the HSP70 inhibitor apoptozole (APZ) to form OTAPZ nanoparticles. The efficacy of this combination was evaluated both in vitro and in vivo, showing efficient tumor targeting and effective MTPTT under NIR laser irradiation. This study presents a promising approach for enhancing MTPTT through balanced photothermal and fluorescence properties, offering new possibilities for cancer treatment.https://www.sciopen.com/article/10.26599/NBE.2025.9290120mild-temperature photothermal therapyphotothermal conversion efficiencynear-infrared–ii imagingheat shock protein |
| spellingShingle | Xuan Sun Zuyuan Zhang Chunbai Xiang Tianhe Qiao Xin Wang Gongcheng Ma Dan Ding Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy Nano Biomedicine and Engineering mild-temperature photothermal therapy photothermal conversion efficiency near-infrared–ii imaging heat shock protein |
| title | Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy |
| title_full | Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy |
| title_fullStr | Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy |
| title_full_unstemmed | Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy |
| title_short | Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy |
| title_sort | donor acceptor donor structured dyes with balanced photothermal conversion efficiency and fluorescence quantum yield for near infrared ii mild temperature photothermal therapy |
| topic | mild-temperature photothermal therapy photothermal conversion efficiency near-infrared–ii imaging heat shock protein |
| url | https://www.sciopen.com/article/10.26599/NBE.2025.9290120 |
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