Hederagenin's uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis.

QR Code

Hederagenin's uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis.

Show other versions (1)

This study explored the uric acid-lowering effects of hederagenin (HD) through molecular docking analysis and a chronic hyperuricemia (HUA) mouse model. Molecular docking was performed to evaluate HD's interactions key urate-regulating proteins, including xanthine oxidase (XOD), ABCG2, OAT1, UR...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ping Chen, Ya-Ni Tian, Jing-Tao Wang, Xiang-Lin Yin, Bao-Sheng Guan, Xue Bai
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0326317
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Hederagenin’s uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis
by: Ping Chen, et al.
Published: (2025-01-01)

EFFECT OF MELINJO SEED EXTRACT ON URIC ACID LEVELS OF HYPERURICEMIC MALE WISTAR RATS
by: Al Ghiffari Muhammad Rayhan, et al.
Published: (2023-01-01)

Effect of Melinjo Seed Extract on GSH Levels of Hyperuricemic Wistar Rats
by: Ardhana Fadhiilah, et al.
Published: (2023-05-01)

Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30
by: HAN Dong, ZHANG Jiahui, JIANG Zhengqiang, CHANG Chang
Published: (2025-05-01)

Screening and evaluation of purines-degrading lactic acid bacteria isolated from traditional fermented foods in Yunnan Province and their uric acid-lowering effects in vivo
by: Zhen Liu, et al.
Published: (2025-07-01)

Hederagenin promotes SIRT6 to attenuate epidural scar formation by aggravating PRMT1 deacetylation
by: Xiao-Chen Fan, et al.
Published: (2025-06-01)

Co-Assembled Nanoparticles Comprising Sorafenib and Hederagenin Derivative for Enhanced Anti-Hepatic Fibrosis Activity
by: Lu M, et al.
Published: (2025-07-01)

Uncovering the molecular targets of phytocannabinoids: mechanistic insights from inverse molecular docking fingerprint approaches
by: Vid Ravnik, et al.
Published: (2025-06-01)

Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD
by: Rang-yue Han, et al.
Published: (2025-09-01)

Dietary supplements for prevention of Alzheimer’s disease: In vivo and in silico molecular docking studies
by: Doha Mohamed, et al.
Published: (2025-02-01)

Mechanistic study of modulating mitochondrial fission and fusion to ameliorate neuropathic pain in mice
by: Liu Xie, et al.
Published: (2025-05-01)

Laccase from <i>Melanocarpus albomyces</i>: Molecular Docking Analysis with First-Generation Tetracyclines Through a Mechanistic Approach
by: José Muñoz-Espinoza, et al.
Published: (2025-05-01)

Widely targeted metabolomics, network pharmacology and molecular docking analyses exploring the mechanistic basis for the antioxidant activity of three golden camellia species
by: Yishan Yang, et al.
Published: (2025-09-01)

Is there an association between osteoporosis and uric acid?
by: N. V. Toroptsova, et al.
Published: (2024-12-01)

From Target Prediction to Mechanistic Insights: Revealing Air Pollution-Driven Mechanisms in Endometrial Cancer via Interpretable Machine Learning and Molecular Docking
by: Hongyao Liu, et al.
Published: (2025-07-01)

Effect of Uric Acid on Blood Glucose Levels
by: Wardhana Wardhana, et al.
Published: (2018-10-01)

Effect of Uric Acid on Blood Glucose Levels
by: Wardhana Wardhana, et al.
Published: (2018-10-01)

Febuxostat Improves Postprandial Glucose Regulation and Insulin Sensitivity in Hyperuricemic Individuals with Prediabetes or Newly Diagnosed Type 2 Diabetes: A Prospective Cohort Study
by: Liu S, et al.
Published: (2025-06-01)

Efficacy of different dosages of common uric acid-lowering medications in gout patients: a network meta-analysis of randomized control trials
by: Xiaojia Zheng, et al.
Published: (2025-06-01)

INTERRRELATION OF URIC SYSTEM PATOLOGY AND DIGESTIVE APPARATUS IN CHILDREN
by: M. V. Bema
Published: (2012-04-01)

Uric Acid in Primary Hyperparathyroidism: Marker, Consequence, or Bystander?
by: Matteo Malagrinò, et al.
Published: (2025-07-01)

Uric Acid as a Risk Factor for Cardiovascular Diseases
by: A. S. Safaryan, et al.
Published: (2022-09-01)

Soluble CD127 potentiates IL‐7 activity in vivo in healthy mice
by: Nawaf A. Aloufi, et al.
Published: (2021-12-01)

The Association Between Uric Acid and Symmetric Dimethylarginine Levels in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
by: Rizki Yaruntradhani Pradwipa, et al.
Published: (2022-09-01)

Mechanistic insight into plasticizer di-(2-ethylhexyl) phthalate as an environmental hazard for abdominal aortic aneurysm: Evidence from in vitro and in vivo studies
by: Yicheng Wang, et al.
Published: (2025-09-01)

Uric acid – the key component of “cardio-reno-metabolic continuum”
by: Zh. D. Kobalava, et al.
Published: (2008-08-01)

Formation of uric acid in grain produced by rhyzopertha dominica (f.)
by: G. A. Zakladnoy, et al.
Published: (2022-07-01)

Uric acid and skeletal muscle status in females with rheumatoid arthritis
by: Olga V. Dobrovolskaya, et al.
Published: (2025-01-01)

Design and construction of dry docks /
by: Mazurkiewicz, B. K.
Published: (1980)

Flexible Protein-Protein Docking
by: Schneider, Sebastian, et al.
Published: (2011)

Quzhuo tongbi formula for reducing gout flare related to uric acid lowering treatment: Study protocol for a multiple-center, randomized, double-blind, placebo, parallel-controlled clinical trial
by: Hejing Pan, et al.
Published: (2025-01-01)

Quzhuo tongbi formula for reducing gout flare related to uric acid lowering treatment: Study protocol for a multiple-center, randomized, double-blind, placebo, parallel-controlled clinical trial.
by: Hejing Pan, et al.
Published: (2025-01-01)

Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice
by: Marwa O Mikati, et al.
Published: (2025-07-01)

The Role of SR-BI in sepsis: leveraging mechanistic insights to advance precision steroid therapy
by: Ling Guo, et al.
Published: (2025-07-01)

The Duke of Puddle Dock : travels in the footsteps of Stamford Raffles /
by: Barley, Nigel
Published: (1991)

The Effects of Land Use Mix on Urban Vitality: A Systemic Conceptualization and Mechanistic Exploration
by: Yuefei Zhuo, et al.
Published: (2025-07-01)

Blood Uric Acid in Mild Cognitive Impairment: A Cross-Sectional Study of Older Chinese Adults
by: Xue L, et al.
Published: (2025-06-01)

Maternal Serum Uric Acid as an Index of Perinatal Outcomes in Severe Preeclampsia
by: Rozhan Yassin Khalil, et al.
Published: (2018-07-01)

Uric acid in atherosclerosis and cardiovascular diseases: innocent bystander or ruthless killer?
by: Giovanni Cimmino, et al.
Published: (2024-06-01)

Uric Acid, Colchicine and Chronic Inflammatory Diseases: A Cardiovascular Perspective
by: Alessia Alunno, et al.
Published: (2025-06-01)