Effects of pertussis toxin and <i>Bordetella pertussis</i> lipo-oligosaccharide on the specific toxicity and potency of whole-cell pertussis vaccines

Effects of pertussis toxin and <i>Bordetella pertussis</i> lipo-oligosaccharide on the specific toxicity and potency of whole-cell pertussis vaccines

Scientific relevance. The content of Bordetella pertussis lipo-oligosaccharide (LOS) and the residual levels of active pertussis toxin (PT) are generally accepted to be the primary factors that determine the reactogenicity of whole-cell pertussis vaccines. To improve the quality of whole-cell pertus...

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Bibliographic Details
Main Authors: I. A. Alekseeva, I. V. Ibragimkhalilova, D. N. Lepekhova
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2023-10-01
Series:Биопрепараты: Профилактика, диагностика, лечение
Subjects:
whole-cell pertussis vaccine
wp vaccine
potency
specific toxicity
vaccine reactogenicity
pertussis component toxic activity
<i>bordetella pertussis</i> lipo-oligosaccharide
pertussis toxin
Online Access:https://www.biopreparations.ru/jour/article/view/488
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