Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problem
This article presents modern aspects of clinical manifestations, laboratory diagnostics and treatment of herpetic keratitis (HK). A total of 68 patients participated in the study. In 75 percent of patients high relapse rates of Herpes Simplex skin infection were revealed in the period before HK onse...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2018-10-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/83 |
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| author | G. M. Chernakova D. Yu. Maychuk T. B. Semenova |
| author_facet | G. M. Chernakova D. Yu. Maychuk T. B. Semenova |
| author_sort | G. M. Chernakova |
| collection | DOAJ |
| description | This article presents modern aspects of clinical manifestations, laboratory diagnostics and treatment of herpetic keratitis (HK). A total of 68 patients participated in the study. In 75 percent of patients high relapse rates of Herpes Simplex skin infection were revealed in the period before HK onset (one-six times per year). Trigger factors for keratitis were thoroughly analyzed. Among them we discovered a number of new ones: the instillation of prostaglandin analogues, paranasal sinus surgery, septoplasty and blepharoplasty. 51 out of 68 patients had active herpetic keratitis, whereas 17 people were in the remission phase. Polymerase chain reaction (PCR) test results for the herpes viruses (HSV, VZV, CMV, EBV, HHV-6) in various body fluids (tears, saliva, blood and urine) from patients with HK are discussed. Herpesvirus DNA was determined in 96 percent of cases (49 out of 51 patients with active HK). Among these 49 patients a monoinfection was detected in 47 percent of cases and mixed infection - in 53 percent. According to the obtained results, we proposed some optimized treatment solutions // Russian Ophthalmological Journal, 2017; 1: 90-7. doi: 10.21516/2072-0076-2017-10-1-90-97. |
| format | Article |
| id | doaj-art-1d29c942553e48de94fc72e4e65f091d |
| institution | Matheson Library |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-1d29c942553e48de94fc72e4e65f091d2025-08-03T19:22:31ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602018-10-01101909710.21516/2072-0076-2017-10-1-90-9783Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problemG. M. Chernakova0D. Yu. Maychuk1T. B. Semenova2Russian Medical Academy of Postgraduate Education, Moscow, RussiaS. Fyodorov Eye Microsurgery Federal State Institution, Moscow, RussiaHerpes Health Centre, Moscow, RussiaThis article presents modern aspects of clinical manifestations, laboratory diagnostics and treatment of herpetic keratitis (HK). A total of 68 patients participated in the study. In 75 percent of patients high relapse rates of Herpes Simplex skin infection were revealed in the period before HK onset (one-six times per year). Trigger factors for keratitis were thoroughly analyzed. Among them we discovered a number of new ones: the instillation of prostaglandin analogues, paranasal sinus surgery, septoplasty and blepharoplasty. 51 out of 68 patients had active herpetic keratitis, whereas 17 people were in the remission phase. Polymerase chain reaction (PCR) test results for the herpes viruses (HSV, VZV, CMV, EBV, HHV-6) in various body fluids (tears, saliva, blood and urine) from patients with HK are discussed. Herpesvirus DNA was determined in 96 percent of cases (49 out of 51 patients with active HK). Among these 49 patients a monoinfection was detected in 47 percent of cases and mixed infection - in 53 percent. According to the obtained results, we proposed some optimized treatment solutions // Russian Ophthalmological Journal, 2017; 1: 90-7. doi: 10.21516/2072-0076-2017-10-1-90-97.https://roj.igb.ru/jour/article/view/83герпетический кератитпцраналоги нуклеозидовпротивовирусная терапияганцикловиррекомбинантный интерферонофтальмоферонherpetic keratitispcrnucleoside analoguesantiviral therapyganciclovirrecombinant interferonoftalmoferon |
| spellingShingle | G. M. Chernakova D. Yu. Maychuk T. B. Semenova Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problem Российский офтальмологический журнал герпетический кератит пцр аналоги нуклеозидов противовирусная терапия ганцикловир рекомбинантный интерферон офтальмоферон herpetic keratitis pcr nucleoside analogues antiviral therapy ganciclovir recombinant interferon oftalmoferon |
| title | Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problem |
| title_full | Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problem |
| title_fullStr | Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problem |
| title_full_unstemmed | Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problem |
| title_short | Сlinical manifestations, diagnostics and therapy of herpetic keratitis today: three facets of one problem |
| title_sort | сlinical manifestations diagnostics and therapy of herpetic keratitis today three facets of one problem |
| topic | герпетический кератит пцр аналоги нуклеозидов противовирусная терапия ганцикловир рекомбинантный интерферон офтальмоферон herpetic keratitis pcr nucleoside analogues antiviral therapy ganciclovir recombinant interferon oftalmoferon |
| url | https://roj.igb.ru/jour/article/view/83 |
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