Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder
Autism spectrum disorder (ASD) is a common developmental neurological disorder that has a significant genetic predisposition and is marked by an early beginning of impairment of social communication and restricted repetitive behaviors, as well as loss of interest in activities. Though it is a common...
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Elsevier
2025-08-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266635462500095X |
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| author | Chetana Ahire Ginpreet Kaur |
| author_facet | Chetana Ahire Ginpreet Kaur |
| author_sort | Chetana Ahire |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a common developmental neurological disorder that has a significant genetic predisposition and is marked by an early beginning of impairment of social communication and restricted repetitive behaviors, as well as loss of interest in activities. Though it is a common condition, pathogenetic mechanisms and etiologic foundations are still unclear; diagnostic strategies and treatments remain inadequate and restricted. Hence, there is an ongoing need to develop safer and more effective therapeutic strategies. Recent findings indicate P2X7 receptor upregulation plays a key role in ASD development through multiple pathological mechanisms, including maternal immune activation, mitochondrial dysfunctioning, oxidative stress, and neuroinflammation. When ATP from outside the cell attaches to P2X7 receptors, it opens channels that let sodium, calcium, and potassium flow in and out of the cell. Long-term receptor stimulation generates large pores in the membrane, potentially facilitating apoptotic and inflammatory mechanisms. So, based on studies using drugs that block the P2X7 receptor and genetic methods, stopping the P2X7 receptor appears to improve the harmful effects related to ASD. So, the therapeutic lead is the brain-permeable P2X7 receptor antagonists that deserve more complete clinical validation.This review discusses how the P2X7 receptor is involved in the development of ASD and looks at possible drug strategies to slow down the disease. |
| format | Article |
| id | doaj-art-1c9df068f0c44ee6976e7cb1d45c56e3 |
| institution | Matheson Library |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-1c9df068f0c44ee6976e7cb1d45c56e32025-07-30T04:17:44ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-08-0147101037Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorderChetana Ahire0Ginpreet Kaur1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’S Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-be University, V.L. Mehta Road, Vile Parle (West), Mumbai, 400056, Maharashtra, IndiaCorresponding author. Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’S NMIMS, Department of Pharmacology, Mumbai, 400056, Maharashtra, India.; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’S Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-be University, V.L. Mehta Road, Vile Parle (West), Mumbai, 400056, Maharashtra, IndiaAutism spectrum disorder (ASD) is a common developmental neurological disorder that has a significant genetic predisposition and is marked by an early beginning of impairment of social communication and restricted repetitive behaviors, as well as loss of interest in activities. Though it is a common condition, pathogenetic mechanisms and etiologic foundations are still unclear; diagnostic strategies and treatments remain inadequate and restricted. Hence, there is an ongoing need to develop safer and more effective therapeutic strategies. Recent findings indicate P2X7 receptor upregulation plays a key role in ASD development through multiple pathological mechanisms, including maternal immune activation, mitochondrial dysfunctioning, oxidative stress, and neuroinflammation. When ATP from outside the cell attaches to P2X7 receptors, it opens channels that let sodium, calcium, and potassium flow in and out of the cell. Long-term receptor stimulation generates large pores in the membrane, potentially facilitating apoptotic and inflammatory mechanisms. So, based on studies using drugs that block the P2X7 receptor and genetic methods, stopping the P2X7 receptor appears to improve the harmful effects related to ASD. So, the therapeutic lead is the brain-permeable P2X7 receptor antagonists that deserve more complete clinical validation.This review discusses how the P2X7 receptor is involved in the development of ASD and looks at possible drug strategies to slow down the disease.http://www.sciencedirect.com/science/article/pii/S266635462500095XAutism spectrum disorderP2X7 receptorMaternal immune activationNeuroinflammationMitochondrial dysfunctioningOxidative stress |
| spellingShingle | Chetana Ahire Ginpreet Kaur Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder Brain, Behavior, & Immunity - Health Autism spectrum disorder P2X7 receptor Maternal immune activation Neuroinflammation Mitochondrial dysfunctioning Oxidative stress |
| title | Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder |
| title_full | Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder |
| title_fullStr | Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder |
| title_full_unstemmed | Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder |
| title_short | Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder |
| title_sort | targeting the p2x7 receptor signaling pathway unlocking therapeutic strategies for autism spectrum disorder |
| topic | Autism spectrum disorder P2X7 receptor Maternal immune activation Neuroinflammation Mitochondrial dysfunctioning Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S266635462500095X |
| work_keys_str_mv | AT chetanaahire targetingthep2x7receptorsignalingpathwayunlockingtherapeuticstrategiesforautismspectrumdisorder AT ginpreetkaur targetingthep2x7receptorsignalingpathwayunlockingtherapeuticstrategiesforautismspectrumdisorder |