String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease
Alzheimer’s disease (AD) affects a significant portion of humanity’s elderly population across the globe. Recent studies have identified Amyloid-Beta 42 (Aβ<sub>42</sub>) as a key biomarker for AD. In this research, we examined the feasibility of using string-shaped electrodes to develop...
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MDPI AG
2025-06-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/13/6/199 |
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| author | Bianca Seufert Sylvia Thomas Arash Takshi |
| author_facet | Bianca Seufert Sylvia Thomas Arash Takshi |
| author_sort | Bianca Seufert |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) affects a significant portion of humanity’s elderly population across the globe. Recent studies have identified Amyloid-Beta 42 (Aβ<sub>42</sub>) as a key biomarker for AD. In this research, we examined the feasibility of using string-shaped electrodes to develop a potentially wearable biosensor for the early detection of AD. Two types of flexible electrochemical electrodes were fabricated using a commercial thread (25% cotton-75% polyester) and an electrospun nanofiber-based string. Decorating the strings with either gold or SiC nanoparticles, several different electrodes were tested to explore their responses to Aβ<sub>42</sub>. Our results show that the nanofiber-based electrode decorated with gold nanoparticles had the highest sensitivity of 1.71 µA/pg.cm and the best limit of detection (LoD) of 8.36 pg/mL. These findings highlight the importance of the string structure in designing highly sensitive sensors. |
| format | Article |
| id | doaj-art-1c99d2e4bb4148e88138c0f11551f8c5 |
| institution | Matheson Library |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-1c99d2e4bb4148e88138c0f11551f8c52025-06-25T13:37:16ZengMDPI AGChemosensors2227-90402025-06-0113619910.3390/chemosensors13060199String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s DiseaseBianca Seufert0Sylvia Thomas1Arash Takshi2Department of Electrical Engineering, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USADepartment of Electrical Engineering, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USADepartment of Electrical Engineering, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USAAlzheimer’s disease (AD) affects a significant portion of humanity’s elderly population across the globe. Recent studies have identified Amyloid-Beta 42 (Aβ<sub>42</sub>) as a key biomarker for AD. In this research, we examined the feasibility of using string-shaped electrodes to develop a potentially wearable biosensor for the early detection of AD. Two types of flexible electrochemical electrodes were fabricated using a commercial thread (25% cotton-75% polyester) and an electrospun nanofiber-based string. Decorating the strings with either gold or SiC nanoparticles, several different electrodes were tested to explore their responses to Aβ<sub>42</sub>. Our results show that the nanofiber-based electrode decorated with gold nanoparticles had the highest sensitivity of 1.71 µA/pg.cm and the best limit of detection (LoD) of 8.36 pg/mL. These findings highlight the importance of the string structure in designing highly sensitive sensors.https://www.mdpi.com/2227-9040/13/6/199electrospun nanofibersflexible string electrodeswearable electronicselectrochemical Amyloid-Beta 42 biosensorcyclic voltammetry (CV) |
| spellingShingle | Bianca Seufert Sylvia Thomas Arash Takshi String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease Chemosensors electrospun nanofibers flexible string electrodes wearable electronics electrochemical Amyloid-Beta 42 biosensor cyclic voltammetry (CV) |
| title | String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease |
| title_full | String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease |
| title_fullStr | String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease |
| title_full_unstemmed | String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease |
| title_short | String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease |
| title_sort | string shaped electrodes for aβ sub 42 sub detection towards early diagnosis of alzheimer s disease |
| topic | electrospun nanofibers flexible string electrodes wearable electronics electrochemical Amyloid-Beta 42 biosensor cyclic voltammetry (CV) |
| url | https://www.mdpi.com/2227-9040/13/6/199 |
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