String-Shaped Electrodes for Aβ<sub>42</sub> Detection Towards Early Diagnosis of Alzheimer’s Disease
Alzheimer’s disease (AD) affects a significant portion of humanity’s elderly population across the globe. Recent studies have identified Amyloid-Beta 42 (Aβ<sub>42</sub>) as a key biomarker for AD. In this research, we examined the feasibility of using string-shaped electrodes to develop...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
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| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/13/6/199 |
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| Summary: | Alzheimer’s disease (AD) affects a significant portion of humanity’s elderly population across the globe. Recent studies have identified Amyloid-Beta 42 (Aβ<sub>42</sub>) as a key biomarker for AD. In this research, we examined the feasibility of using string-shaped electrodes to develop a potentially wearable biosensor for the early detection of AD. Two types of flexible electrochemical electrodes were fabricated using a commercial thread (25% cotton-75% polyester) and an electrospun nanofiber-based string. Decorating the strings with either gold or SiC nanoparticles, several different electrodes were tested to explore their responses to Aβ<sub>42</sub>. Our results show that the nanofiber-based electrode decorated with gold nanoparticles had the highest sensitivity of 1.71 µA/pg.cm and the best limit of detection (LoD) of 8.36 pg/mL. These findings highlight the importance of the string structure in designing highly sensitive sensors. |
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| ISSN: | 2227-9040 |