Anionic Lipid Catalyzes the Generation of Cytotoxic Insulin Oligomers

Anionic Lipid Catalyzes the Generation of Cytotoxic Insulin Oligomers

The misfolding and aggregation of proteins into amyloidogenic assemblies are key features of several metabolic and neurodegenerative diseases. Human insulin has long been known to form amyloid fibrils under various conditions, which affects its bioavailability and function. Clinically, insulin aggre...

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Bibliographic Details
Main Authors: Jhinuk Saha, Audrey Wolszczak, Navneet Kaur, Malitha C. Dickwella Widanage, Samuel D. McCalpin, Riqiang Fu, Jamel Ali, Ayyalusamy Ramamoorthy
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomolecules
Subjects:
insulin
amyloids
aggregation
lipids
Online Access:https://www.mdpi.com/2218-273X/15/7/994
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