Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned Rabbits
The present study was conducted to investigate the effects of dietary addition of tributyrin on growth performance, antioxidant and intestinal health in weaned rabbits. Weaned Hyla rabbits (35 d, <i>n</i> = 1280) of similar body weight were randomly divided into four groups (eight replic...
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2025-06-01
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| author | Nanbin Zhang Xianghui Li Huijie Xu Fuchang Li Lei Liu |
| author_facet | Nanbin Zhang Xianghui Li Huijie Xu Fuchang Li Lei Liu |
| author_sort | Nanbin Zhang |
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| description | The present study was conducted to investigate the effects of dietary addition of tributyrin on growth performance, antioxidant and intestinal health in weaned rabbits. Weaned Hyla rabbits (35 d, <i>n</i> = 1280) of similar body weight were randomly divided into four groups (eight replicates per group, 40 rabbits per replicate), fed diets with 0, 0.1%, 0.2% or 0.4% tributyrin addition. A 3-day pre-experimental period was followed by a 36-day trial period. Our results show that dietary addition of 0.2% tributyrin significantly increased the average daily gain (ADG) and final body weight (FBW) of rabbits, and decreased the diarrhea rate (<i>p</i> < 0.05). Dietary addition of 0.1% and 0.2% tributyrin significantly increased the average carcass weight and liver weight (<i>p</i> < 0.05). In the liver, dietary addition of tributyrin increased the content of glutathione peroxidase (GSH-PX) and total superoxide dismutase (T-SOD) compared with the control group (<i>p</i> < 0.05). Dietary addition of 0.1% and 0.2% tributyrin significantly increased the serum GSH-PX level (<i>p</i> < 0.05). Dietary addition of 0.2% tributyrin significantly increased the serum T-SOD level (<i>p</i> < 0.05). Dietary addition of 0.2% tributyrin significantly increased villus height/crypt depth (V/C) in the duodenum (<i>p</i> < 0.05). Dietary addition of 0.1–0.4% tributyrin significantly increased V/C in the jejunum (<i>p</i> < 0.05). Dietary addition of 0.1–0.2% tributyrin significantly increased the V/C in the ileum, but significantly decreased the content of serum diamine oxidase (DAO) and of D-lactic acid in serum (<i>p</i> < 0.05). In conclusion, dietary addition of tributyrin can improve the production performance and antioxidant ability of liver and serum, and improve the intestinal health by decreasing the diarrhea rate and the intestinal permeability and improving intestinal morphology in weaned rabbits. Based on the present results, the optimal level of tributyrin is 0.2% in the weaned rabbit diet. |
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| spelling | doaj-art-1c24d9bd6c8445f9b1698a3e52a10a302025-07-11T14:35:02ZengMDPI AGAnimals2076-26152025-06-011513192310.3390/ani15131923Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned RabbitsNanbin Zhang0Xianghui Li1Huijie Xu2Fuchang Li3Lei Liu4Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, Department of Animal Science and Technology, Shandong Agricultural University, Taian 271017, ChinaKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, Department of Animal Science and Technology, Shandong Agricultural University, Taian 271017, ChinaKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, Department of Animal Science and Technology, Shandong Agricultural University, Taian 271017, ChinaKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, Department of Animal Science and Technology, Shandong Agricultural University, Taian 271017, ChinaKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, Department of Animal Science and Technology, Shandong Agricultural University, Taian 271017, ChinaThe present study was conducted to investigate the effects of dietary addition of tributyrin on growth performance, antioxidant and intestinal health in weaned rabbits. Weaned Hyla rabbits (35 d, <i>n</i> = 1280) of similar body weight were randomly divided into four groups (eight replicates per group, 40 rabbits per replicate), fed diets with 0, 0.1%, 0.2% or 0.4% tributyrin addition. A 3-day pre-experimental period was followed by a 36-day trial period. Our results show that dietary addition of 0.2% tributyrin significantly increased the average daily gain (ADG) and final body weight (FBW) of rabbits, and decreased the diarrhea rate (<i>p</i> < 0.05). Dietary addition of 0.1% and 0.2% tributyrin significantly increased the average carcass weight and liver weight (<i>p</i> < 0.05). In the liver, dietary addition of tributyrin increased the content of glutathione peroxidase (GSH-PX) and total superoxide dismutase (T-SOD) compared with the control group (<i>p</i> < 0.05). Dietary addition of 0.1% and 0.2% tributyrin significantly increased the serum GSH-PX level (<i>p</i> < 0.05). Dietary addition of 0.2% tributyrin significantly increased the serum T-SOD level (<i>p</i> < 0.05). Dietary addition of 0.2% tributyrin significantly increased villus height/crypt depth (V/C) in the duodenum (<i>p</i> < 0.05). Dietary addition of 0.1–0.4% tributyrin significantly increased V/C in the jejunum (<i>p</i> < 0.05). Dietary addition of 0.1–0.2% tributyrin significantly increased the V/C in the ileum, but significantly decreased the content of serum diamine oxidase (DAO) and of D-lactic acid in serum (<i>p</i> < 0.05). In conclusion, dietary addition of tributyrin can improve the production performance and antioxidant ability of liver and serum, and improve the intestinal health by decreasing the diarrhea rate and the intestinal permeability and improving intestinal morphology in weaned rabbits. Based on the present results, the optimal level of tributyrin is 0.2% in the weaned rabbit diet.https://www.mdpi.com/2076-2615/15/13/1923tributyrinproduction performanceantioxidantintestinal healthrabbit |
| spellingShingle | Nanbin Zhang Xianghui Li Huijie Xu Fuchang Li Lei Liu Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned Rabbits Animals tributyrin production performance antioxidant intestinal health rabbit |
| title | Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned Rabbits |
| title_full | Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned Rabbits |
| title_fullStr | Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned Rabbits |
| title_full_unstemmed | Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned Rabbits |
| title_short | Dietary Addition of Tributyrin Improved the Production Performance, Antioxidant Ability and Intestinal Health in Weaned Rabbits |
| title_sort | dietary addition of tributyrin improved the production performance antioxidant ability and intestinal health in weaned rabbits |
| topic | tributyrin production performance antioxidant intestinal health rabbit |
| url | https://www.mdpi.com/2076-2615/15/13/1923 |
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