ANTIARRHYTHMIC ACTIVITY MONOGAMISTIC AMIDES AND HYDRAZIDES 1,4-DICARBOXYLIC ACIDS
The antiarrhythmic activity of 19 derivatives 1,4-dicarboxylic acids in experiments on white mice on the model of chlorocalcium arrhythmia and acute toxicity of 6 compounds. As a standard, the drug «Lidocaine» was used. Two compounds showed an antiarrhythmic effect exceeding the standard effect by 6...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
|
| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/592 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The antiarrhythmic activity of 19 derivatives 1,4-dicarboxylic acids in experiments on white mice on the model of chlorocalcium arrhythmia and acute toxicity of 6 compounds. As a standard, the drug «Lidocaine» was used. Two compounds showed an antiarrhythmic effect exceeding the standard effect by 6 times [ED50=7.3 mg/kg (5.3÷10.0)] and 3 times [ED50=6.9 mg/kg (5.0÷9.5)]. 4-Aminobenzoylhydrazide itaconic acid has antiarrhythmic activity, the same derivatives of succinic, maleic, citraconic and dimethylmaleic acids are not active. Isonicotinoylhydrazide phthalic acid exceeds the antiarrhythmic activity of the standard, the same hydrazides of maleic, dimethylmaleic and tetrachlorophthalic acids do not possess an antiarrhythmic effect. |
|---|---|
| ISSN: | 2305-2066 2658-5049 |